从癌症患者血清中分离及维生素D3酮衍生物的分子结构测定。
Isolation from the serum of cancer patients and molecular structure determination of a ketone derivative of D3 vitamin.
作者信息
Rougereau A, Person O, Rougereau G
出版信息
Int J Vitam Nutr Res. 1987;57(1):19-23.
In a previous article we have reported our finding of an unknown vitamin derivative in the serum of cancer patients and in rats transplanted by a malignant tumor. Analysis of this compound extracted from serum of cancer patients, was carried out by I.R., U.V., mass spectrography and nuclear magnetic resonance (N.M.R.) determination. This analysis led us to the conclusion that the compound was a ketone derivative of D3 vitamin: 1-ceto-24-methyl-25-hydroxycholecalciferol, provisionally designated D3C. Enzymatic pathways involved in the biosynthesis of this substance and its possible role in normal and pathological cell division are discussed.
在之前的一篇文章中，我们报道了在癌症患者血清以及移植了恶性肿瘤的大鼠血清中发现一种未知维生素衍生物的情况。对从癌症患者血清中提取的这种化合物进行了红外光谱、紫外光谱、质谱分析以及核磁共振测定。这些分析使我们得出结论，该化合物是D3维生素的一种酮衍生物：1-酮基-24-甲基-25-羟基胆钙化醇，暂定为D3C。文中讨论了该物质生物合成所涉及的酶促途径及其在正常和病理细胞分裂中可能发挥的作用。
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