Sobh M A, el-Sharabasy M M
Int Urol Nephrol. 1987;19(1):21-6. doi: 10.1007/BF02549673.
Three groups of female mongrel dogs were used. In each dog right nephrectomy was performed. In the first group, 60-min complete occlusion of the left renal artery was followed by 50.4% reduction in RBF (P less than 0.05), 53.4% reduction in GFR (P less than 0.01) and 46.7% reduction in urine flow rate (UV) (P less than 0.05). These haemodynamic changes were accompanied by a significant (P less than 0.01) increase in urinary enzyme activity. In the second group, following Verapamil 0.5 mg/kg i.v. bolus, there was diuresis and natriuresis, urine flow rate (UV) increased by 39% and UNaV by 60% (P greater than 0.05); there were no changes in RBF or GFR. In the third group, pretreatment with Verapamil prior to the arterial occlusion modified the deleterious effects of the 60-min renal ischaemia. RBF decreased by 9.4%, GFR by 28.5% and UV by 11.1% (P greater than 0.05); there was no change in the urinary enzyme activity. It is concluded that Verapamil can protect against ischaemic renal damage.
使用了三组雌性杂种犬。对每组犬均进行了右肾切除术。在第一组中，左肾动脉完全闭塞60分钟后，肾血流量（RBF）降低了50.4%（P<0.05），肾小球滤过率（GFR）降低了53.4%（P<0.01），尿流率（UV）降低了46.7%（P<0.05）。这些血流动力学变化伴随着尿酶活性显著升高（P<0.01）。在第二组中，静脉推注0.5mg/kg维拉帕米后，出现利尿和利钠作用，尿流率（UV）增加了39%，尿钠排泄率（UNaV）增加了60%（P>0.05）；肾血流量（RBF）和肾小球滤过率（GFR）无变化。在第三组中，在动脉闭塞前用维拉帕米预处理可减轻60分钟肾缺血的有害影响。肾血流量（RBF）降低了9.4%，肾小球滤过率（GFR）降低了28.5%，尿流率（UV）降低了11.1%（P>0.05）；尿酶活性无变化。结论是维拉帕米可预防缺血性肾损伤。
