腺苷蛋氨酸联合四磨汤治疗新生儿黄疸的疗效

Efficacy of adenosylmethionine combined with Si Mo Tang in treatment of neonatal jaundice.

作者信息

Li Ling, Wang Jingqun, Geng Shuxia, Liu Fang, Ping Lili, Gu Xiaohong, Fan Xueai, Yang Mei, Liang Lixia, Guo Wei

机构信息

Department of Neonatology, Xingtai People's Hospital Xingtai, Hebei, China.

Department of Neonatology, Bethune International Peace Hospital Shijiazhuang, Hebei, China.

出版信息

Am J Transl Res. 2022 Jun 15;14(6):3926-3935. eCollection 2022.

PMID:35836853

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9274584/

Abstract

OBJECTIVE

To investigate the efficacy of S-adenosylmethionine (SAM-e) combined with Si Mo Tang in the treatment of neonatal jaundice and its effect on liver function, cardiac enzymes, immune function, serum transferrin (TRF) and C-reactive protein (CRP) levels.

METHODS

The clinical data of 149 infants with neonatal jaundice were collected retrospectively. The infants were grouped according to the treatment methods. All neonates were treated with blue light phototherapy. Besides, group A was treated with SAM-e, group B was treated with Si Mo Tang, and group C was treated with SAM-e combined with Si Mo Tang. The treatment efficacy, serum bilirubin level, neonatal behavioral neurological assessment (NBNA) score, liver function, cardiac enzymes, immune function, serum TRF and CRP level were compared among the three groups before and after treatment.

RESULTS

The total effective rate of treatment in group C was 96.00%, which was higher than group A (73.47%) and group B (78.00%) (P < 0.05), but no significant difference was observed between groups A and B (P > 0.05). Compared with groups A and B, group C had higher NBNA scores, lower serum bilirubin levels, and lower serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase-MB (CK-MB) levels (all P < 0.05); however, there was no statistical differences in NBNA scores, serum bilirubin levels, serum AST and ALT, LDH, CK and CK-MB levels between group A and group B (all P > 0.05). Compared with groups A and B, group C showed higher CD4, CD4/CD8, TRF levels and lower serum CRP levels (P < 0.05), while there was no statistical differences in CD4, CD4/CD8, CD8, TRF levels and serum CRP levels between group A and group B (all P > 0.05).

CONCLUSION

SAM-e combined with Si Mo Tang promoted the regression of jaundice, improved liver function, neurodevelopmental conditions and the myocardial enzyme spectrum, reduced the level of inflammation, and improved the immunity of newborns with neonatal jaundice.

摘要

目的

探讨S-腺苷甲硫氨酸（SAM-e）联合四磨汤治疗新生儿黄疸的疗效及其对肝功能、心肌酶、免疫功能、血清转铁蛋白（TRF）和C反应蛋白（CRP）水平的影响。

方法

回顾性收集149例新生儿黄疸患儿的临床资料。根据治疗方法将患儿分组。所有新生儿均采用蓝光照射治疗。此外，A组采用SAM-e治疗，B组采用四磨汤治疗，C组采用SAM-e联合四磨汤治疗。比较三组治疗前后的治疗效果、血清胆红素水平、新生儿行为神经评定（NBNA）评分、肝功能、心肌酶、免疫功能、血清TRF和CRP水平。

结果

C组治疗总有效率为96.00%，高于A组（73.47%）和B组（78.00%）（P<0.05），但A组和B组之间差异无统计学意义（P>0.05）。与A组和B组相比，C组NBNA评分更高，血清胆红素水平更低，血清天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、乳酸脱氢酶（LDH）、肌酸激酶（CK）和肌酸激酶同工酶（CK-MB）水平更低（均P<0.05）；然而，A组和B组之间的NBNA评分、血清胆红素水平、血清AST和ALT、LDH、CK和CK-MB水平差异均无统计学意义（均P>0.05）。与A组和B组相比，C组CD4、CD4/CD8、TRF水平更高，血清CRP水平更低（P<0.05），而A组和B组之间的CD4、CD4/CD8、CD8、TRF水平和血清CRP水平差异均无统计学意义（均P>0.05）。