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World J Emerg Med. 2022;13(4):313-321. doi: 10.5847/wjem.j.1920-8642.2022.062.
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Peg-Asparaginase-Associated Pancreatitis in Chemotherapy-Treated Pediatric Patients: A 5-Year Retrospective Study.化疗治疗的儿科患者中聚乙二醇化天冬酰胺酶相关性胰腺炎：一项5年回顾性研究
Front Oncol. 2020 Oct 28;10:538779. doi: 10.3389/fonc.2020.538779. eCollection 2020.
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Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen.采用儿童启发式方案治疗的成人急性淋巴细胞白血病患者中天冬酰胺酶相关肝毒性、胰腺炎和血栓形成事件的发生率。
J Oncol Pharm Pract. 2018 Jun;24(4):299-308. doi: 10.1177/1078155217701291. Epub 2017 Mar 29.
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L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.L-天冬酰胺酶诱导的严重坏死性胰腺炎经皮引流治疗成功。
Pediatr Blood Cancer. 2005 Jan;44(1):95-7. doi: 10.1002/pbc.20187.
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Successful management of severe L-asparaginase-associated pancreatitis by continuous regional arterial infusion of protease inhibitor and antibiotic.通过持续区域动脉输注蛋白酶抑制剂和抗生素成功治疗严重的L-天冬酰胺酶相关性胰腺炎。
Cancer. 2008 Sep 15;113(6):1362-9. doi: 10.1002/cncr.23716.
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Predicting asparaginase-associated pancreatitis.预测天冬酰胺酶相关性胰腺炎。
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[Severe acute pancreatitis in children receiving asparaginase: multicenter retrospective study].[接受门冬酰胺酶治疗的儿童重症急性胰腺炎：多中心回顾性研究]
Arch Pediatr. 2005 Jan;12(1):34-41. doi: 10.1016/j.arcped.2004.07.020.
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Retraction: Peg-Asparaginase-Associated Pancreatitis in Chemotherapy-Treated Pediatric Patients: A 5-Year Retrospective Study.撤稿声明：化疗治疗的儿科患者中培门冬酶相关性胰腺炎：一项5年回顾性研究。
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Successful Management of l-Asparaginase-Associated Pancreatitis With Octreotide and Pegylated Asparaginase in 2 Patients With Acute Lymphoblastic Leukemia: Is There a Different Rare Warning Sign of Hypoglycemia for l-Asparaginase-Associated Pancreatitis?2 例急性淋巴细胞白血病患者应用奥曲肽和聚乙二醇化 asparaginase 成功治疗 l-天冬酰胺酶相关性胰腺炎：l-天冬酰胺酶相关性胰腺炎是否存在低血糖的不同罕见预警信号？
Clin Ther. 2020 Apr;42(4):e82-e86. doi: 10.1016/j.clinthera.2020.02.015. Epub 2020 Mar 14.
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Successful use of octreotide as a chemoprotectant for prevention of PEG-asparaginase-induced pancreatitis.奥曲肽作为化学保护剂成功用于预防聚乙二醇天冬酰胺酶诱导的胰腺炎。
Pharmacotherapy. 2014 Aug;34(8):e149-51. doi: 10.1002/phar.1460.

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Risk factors and outcome of asparaginase-associated pancreatitis in pediatric acute lymphoblastic leukemia.儿童急性淋巴细胞白血病中天冬酰胺酶相关性胰腺炎的危险因素及预后
Front Oncol. 2025 Jun 26;15:1606261. doi: 10.3389/fonc.2025.1606261. eCollection 2025.
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Asparaginase-associated Pancreatitis Complicated by Pancreatic Fluid Collection Treated with Endoscopic Cistogastrostomy in Pediatric Acute Lymphoblastic Leukemia: A Case Report and Systematic Review of the Literature.小儿急性淋巴细胞白血病中伴胰液积聚的天冬酰胺酶相关性胰腺炎经内镜囊肿胃造口术治疗：一例报告及文献系统综述
Clin Hematol Int. 2023 Dec 20;5(4):51-61. doi: 10.46989/001c.90958. eCollection 2023.

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1
Optimizing pegylated asparaginase use: An institutional guideline for dosing, monitoring, and management.优化聚乙二醇化天冬酰胺酶的使用：给药、监测及管理的机构指南
J Oncol Pharm Pract. 2020 Jan;26(1):74-92. doi: 10.1177/1078155219838316. Epub 2019 Mar 27.
2
Safety profile of a single pegylated asparaginase (PEG-ASP) dose in remission induction for acute lymphoblastic leukemia (ALL).单剂量聚乙二醇化门冬酰胺酶（PEG-ASP）在急性淋巴细胞白血病（ALL）缓解诱导中的安全性概况。
Neoplasma. 2018 Nov 15;65(6):993-997. doi: 10.4149/neo_2018_180214N121. Epub 2018 Jun 17.
3
Asparaginase-associated pancreatitis in childhood acute lymphoblastic leukaemia: an observational Ponte di Legno Toxicity Working Group study.儿童急性淋巴细胞白血病中与天冬酰胺酶相关的胰腺炎：观察性 Ponte di Legno 毒性工作组研究。
Lancet Oncol. 2017 Sep;18(9):1238-1248. doi: 10.1016/S1470-2045(17)30424-2. Epub 2017 Jul 20.
4
Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review.天冬酰胺酶相关性胰腺炎的危险因素：一项系统评价
J Clin Gastroenterol. 2017 Nov/Dec;51(10):907-913. doi: 10.1097/MCG.0000000000000827.
5
Asparaginase-associated pancreatitis: a study on phenotype and genotype in the NOPHO ALL2008 protocol. asparaginase 相关胰腺炎：在 NOPHO ALL2008 方案中进行表型和基因型研究。
Leukemia. 2017 Feb;31(2):325-332. doi: 10.1038/leu.2016.203. Epub 2016 Jul 25.
6
A Pilot Study of Intensified PEG-Asparaginase in High-risk Acute Lymphoblastic Leukemia: Children's Oncology Group Study AALL08P1.强化聚乙二醇化天冬酰胺酶治疗高危急性淋巴细胞白血病的一项初步研究：儿童肿瘤协作组AALL08P1研究
J Pediatr Hematol Oncol. 2016 Aug;38(6):409-17. doi: 10.1097/MPH.0000000000000589.
7
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus.儿童急性淋巴细胞白血病治疗中 14 种严重毒性效应的共识定义：德尔菲共识。
Lancet Oncol. 2016 Jun;17(6):e231-e239. doi: 10.1016/S1470-2045(16)30035-3.
8
Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.急性淋巴细胞白血病患者急性胰腺炎的临床和遗传危险因素
J Clin Oncol. 2016 Jun 20;34(18):2133-40. doi: 10.1200/JCO.2015.64.5812. Epub 2016 Apr 25.
9
Intravenous pegylated asparaginase versus intramuscular native Escherichia coli L-asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial.静脉注射聚乙二醇化门冬酰胺酶与新诊断的儿童急性淋巴细胞白血病（DFCI 05-001）中的肌内天然大肠杆菌 L-门冬酰胺酶的比较：一项随机、开放标签的 3 期试验。
Lancet Oncol. 2015 Dec;16(16):1677-90. doi: 10.1016/S1470-2045(15)00363-0. Epub 2015 Nov 6.
10
Serial Ultrasound Monitoring for Early Recognition of Asparaginase Associated Pancreatitis in Children With Acute Lymphoblastic Leukemia.连续超声监测以早期识别急性淋巴细胞白血病患儿中天冬酰胺酶相关性胰腺炎
Pediatr Hematol Oncol. 2015;32(7):474-81. doi: 10.3109/08880018.2015.1055868. Epub 2015 Aug 13.

Asparaginase-associated pancreatitis in chemotherapy-treated pediatric patients: a five-year retrospective study.

作者信息

Liu Chen-Xi, Zhang Yun-Yu, Yang Qiu-Shi, Shen Shu-Hong, Chen Jing, Tang Yan-Jing, Chen Chang-Cheng, Wang Zhuo, Li Bi-Ru, Qian Juan, Wang Ying, Hu Wen-Ting, Ning Bo-Tao

机构信息

Department of Pediatric Hematology and Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Department of Pediatric Intensive Care Unit, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

出版信息

World J Emerg Med. 2022;13(4):313-321. doi: 10.5847/wjem.j.1920-8642.2022.062.

DOI:10.5847/wjem.j.1920-8642.2022.062
PMID:35837564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9233968/
Abstract
摘要