Ek A, Andersson K E, Gullberg B, Ulmsten U
Scand J Urol Nephrol. 1978;12(2):105-10. doi: 10.3109/00365597809179974.
Twenty-five women with stress incontinence of urine were given an alpha-adrenoceptor stimulating agent (norephedrine) and a placebo during respective 14-day periods according to a double-blind cross-over schedule. The results were classified as the patient's own assessment of therapeutic effect and as change in urethral closure pressure profile measured by a microtransducer catheter. Norephedrine had a significant therapeutic effect on the symptom stress incontinence and produced significant increase in maximum urethral pressure and maximum urethral closure pressure in the lithotomy and the erect position. Reduction of incontinence was associated with increase in maximum urethral closure pressure. The sum therapeutic effect was of moderate degree.
25名压力性尿失禁女性患者，按照双盲交叉试验方案，分别在14天内给予α-肾上腺素能受体兴奋剂（去甲麻黄碱）和安慰剂。结果按照患者对治疗效果的自我评估以及通过微型传感器导管测量的尿道闭合压曲线变化进行分类。去甲麻黄碱对压力性尿失禁症状有显著治疗效果，在截石位和直立位时可使最大尿道压和最大尿道闭合压显著升高。尿失禁减轻与最大尿道闭合压升高相关。总体治疗效果为中度。
