Obrink A, Bunne G
Scand J Urol Nephrol. 1978;12(3):205-8. doi: 10.3109/00365597809179717.
The urethra is innervated by adrenergic fibres and its smooth muscle is equipped mainly with alpha-adrenoreceptors. Norephedrine chloride, which is an alpha-stimulating agent, has been proposed as therapy for stress incontinence, since it was shown to increase the maximum urethral pressure at rest. For further study of the effect of norephedrine chloride on the urethal closure pressure at rest and in a dynamic situation, we examined ten severely stress-incontinent women before and after three weeks of treatment with this agent (100 mg by mouth twice daily). The urethral closure pressure at rest, between coughs of varied strength and at the precise moment of stress were recorded. The margin to leakage, the tone of the urethral wall and the transmission of pressure from abdomen to urethra were also among the estimated factors. No improvement was found in any of these respects. Alpha stimulation in this form therefore seems ineffective in severe stress incontinence and is not an alternative to surgical treatment.
尿道由肾上腺素能纤维支配，其平滑肌主要配备有α - 肾上腺素受体。去氧麻黄碱（一种α刺激剂）已被提议用于治疗压力性尿失禁，因为它被证明能增加静息时的最大尿道压力。为了进一步研究去氧麻黄碱对静息和动态情况下尿道闭合压力的影响，我们对10名重度压力性尿失禁女性在使用该药物（每日两次，每次口服100毫克）治疗三周前后进行了检查。记录了静息时、不同强度咳嗽时以及压力精确时刻的尿道闭合压力。估计因素还包括漏尿余量、尿道壁张力以及从腹部到尿道的压力传递。在这些方面均未发现改善。因此，这种形式的α刺激在重度压力性尿失禁中似乎无效，也不是手术治疗的替代方法。
