Spry C J
Schweiz Med Wochenschr. 1978 Oct 14;108(41):1572-6.
The ability of eosinophils to express Fc and C3b receptors can alter in vivo and in vitro, and with these membrane receptors eosinophils can bind to IgG or C3b coated metazoan parasites and cells, some of which are killed. In addition, IgG and C3b coated particles can induce eosinophils to secrete their granule contents which include distinct basic (cationic) proteins and peroxidase. These may bind to surfaces or cell membranes where they could initiate complement activation, coagulation or kinin generation. The high incidence of thrombi and endocardial cell damage in patients with persistent eosinophilia (even when it is induced by malignant disease), supports this possibility. Endocardial damage which leads to Löffler's cardiomyopathy may be induced by these products being secreted from circulating eosinophils which have a prolonged blood half-life in hypereosinophilic states. It is concluded that eosinophils have an active role in inducting inflammatory processes in tissues, and that they are important effector cells in some types of parasitic and allergic diseases. Analyses of the way in which these effects occur may show how eosinophils carry out their functions in tissues.
嗜酸性粒细胞表达Fc和C3b受体的能力在体内和体外均可发生变化，借助这些膜受体，嗜酸性粒细胞可与包被有IgG或C3b的后生动物寄生虫及细胞结合，其中一些会被杀死。此外，包被有IgG和C3b的颗粒可诱导嗜酸性粒细胞分泌其颗粒内容物，其中包括独特的碱性（阳离子）蛋白和过氧化物酶。这些物质可能会结合到表面或细胞膜上，进而引发补体激活、凝血或激肽生成。持续性嗜酸性粒细胞增多症患者（即使是由恶性疾病引起）血栓形成和心内膜细胞损伤的高发生率支持了这种可能性。导致吕弗勒心肌病的心内膜损伤可能是由循环嗜酸性粒细胞分泌的这些产物引起的，在嗜酸性粒细胞增多状态下，这些细胞在血液中的半衰期延长。得出的结论是，嗜酸性粒细胞在诱导组织炎症过程中发挥积极作用，并且它们是某些类型寄生虫病和过敏性疾病中的重要效应细胞。对这些效应发生方式的分析可能会揭示嗜酸性粒细胞在组织中是如何发挥其功能的。
