Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea.
Graefes Arch Clin Exp Ophthalmol. 2022 Sep;260(9):2791-2798. doi: 10.1007/s00417-022-05750-2. Epub 2022 Jul 15.
With the recent advent of high-resolution optical coherence tomography (OCT), atypical epiretinal tissue (AET), also known as epiretinal proliferation, has been frequently noted in various pathologies. AET presents as premacular tissue with homogenous medium reflectivity over the internal limiting membrane on OCT. Although AET is most frequently associated with a lamellar hole (LH), some cases of macular hole (MH) also accompany AET at the edge of the hole. MH with AET has been reported to have worse clinical and surgical outcomes than MH without AET. The imaging and histopathological findings of AET imply that the development of MH with AET may not have been driven by vitreofoveal traction. Instead, MH with AET might have evolved from LH with AET. This mini-review encompassed relevant studies on MH with AET published to date and explained the clinical, prognostic, and pathogenic significance of AET in MH in detail.
随着高分辨率光学相干断层扫描（OCT）的出现，各种病变中经常会出现不典型的视网膜内组织（AET），也称为视网膜内增殖。AET 在 OCT 上表现为黄斑前组织，内界膜上有均匀的中等反射率。尽管 AET 最常与板层裂孔（LH）相关，但一些黄斑裂孔（MH）病例的孔边缘也伴有 AET。伴有 AET 的 MH 的临床和手术结果比不伴有 AET 的 MH 差。AET 的影像学和组织病理学发现表明，伴有 AET 的 MH 的发展可能不是由玻璃体视网膜牵引引起的。相反，伴有 AET 的 MH 可能是由伴有 AET 的 LH 演变而来。这篇小型综述涵盖了迄今为止发表的关于伴有 AET 的 MH 的相关研究，并详细解释了 AET 在 MH 中的临床、预后和发病意义。
