Thompson J P, Senior D F, Pinson D M, Moriello K A
J Am Vet Med Assoc. 1987 May 15;190(10):1311-2.
Two weeks after daily topical application of hexachlorophene, a 4-week-old female kitten developed cardiovascular collapse, corneal ulcers, trembling, lethargy, and weakness. The kitten was euthanatized. At necropsy, the tissues appeared macroscopically normal; however, microscopic examination of tissue specimens indicated status spongiosis, astrocytosis, and microgliosis of the cerebral and cerebellar white matter and corticospinal tracts. Neuronal cell bodies forming the affected white matter were intact, indicating that demyelination may have been the cause of the lesions. The neurologic lesions were considered compatible with those of hexachlorophene-induced toxicosis.
在每日局部应用六氯酚两周后，一只4周龄的雌性小猫出现心血管衰竭、角膜溃疡、颤抖、嗜睡和虚弱症状。这只小猫被实施了安乐死。尸检时，组织在宏观上看起来正常；然而，对组织标本的显微镜检查显示大脑和小脑白质以及皮质脊髓束出现海绵状变性、星形细胞增多和小胶质细胞增生。形成受影响白质的神经元细胞体完好无损，表明脱髓鞘可能是病变的原因。这些神经病变被认为与六氯酚诱导的中毒病变相符。
