Research Institute of Clinical Medicine of Jeonbuk National University and Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju-si, Republic of Korea.
Department of Emergency Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
Medicine (Baltimore). 2022 Jul 15;101(28):e29355. doi: 10.1097/MD.0000000000029355.
Sodium nitrite is a potent oxidizing agent that impairs oxygen transport and delivery through methemoglobin formation. Clinical manifestations are known to induce methemoglobinemia, dysrhythmia, hypotension, and even death. While accidental intoxication of sodium nitrite by contaminated water and food has previously occurred, there has been a substantial upsurge in suicide intoxication in recent years.
We present case reports of 2 patients who attempted suicide by sodium nitrite after ordering a "suicide powder" on the internet market. They were brought to the emergency department after attempting suicide by ingesting sodium nitrite. They experienced dyspnea, cyanosis, and mild nausea.
Based on their history and blood tests, methemoglobinemia was initially diagnosed.
The patients received methylene blue antidotal therapy in the emergency department. The patients were discharged after neuropsychiatric evaluation and treatment for mental illness, suicidal ideation, and suicide attempts. They informed us of how simple and easy it was for them to buy sodium nitrite for suicidal purposes.
With widely shared information on the usage of sodium nitrite for suicide and the absence of proper regulation, the incidence of acute poisoning will increase. This increases physicians' chances of encountering unexplained cyanosis and methemoglobinemia. Clinical suspicion of sodium nitrite intoxication is warranted in cases of unexplained cyanosis or methemoglobinemia. We want to highlight how simple and easy it is to buy sodium nitrite for suicidal purposes.
亚硝酸钠是一种强氧化剂,可通过形成高铁血红蛋白而损害氧气的运输和输送。已知其临床表现可引起高铁血红蛋白血症、心律失常、低血压,甚至死亡。虽然以前曾发生过因受污染的水和食物意外摄入亚硝酸钠而中毒的情况,但近年来自杀性中毒的情况有了大幅增加。
我们报告了 2 例患者的病例,他们在互联网市场上订购了“自杀粉”后试图用亚硝酸钠自杀。他们在服下亚硝酸钠后被送到急诊室。他们出现呼吸困难、发绀和轻度恶心。
根据他们的病史和血液检查,最初诊断为高铁血红蛋白血症。
患者在急诊科接受了亚甲蓝解毒治疗。经过神经精神评估以及对精神疾病、自杀意念和自杀企图的治疗后,患者出院。他们告诉我们,他们很容易就能买到亚硝酸钠用于自杀目的。
随着关于亚硝酸钠自杀用途的信息广泛传播,以及缺乏适当的监管,急性中毒的发生率将会增加。这增加了医生遇到不明原因发绀和高铁血红蛋白血症的几率。在出现不明原因发绀或高铁血红蛋白血症的情况下,应怀疑亚硝酸钠中毒。我们想强调的是,购买亚硝酸钠用于自杀目的是多么容易。