Clinic Laboratory of the Affiliated Hospital of Inner Mongolia Medical University, Huimin district, Hohhot, P.R. China.
Medicine (Baltimore). 2022 Jul 15;101(28):e29545. doi: 10.1097/MD.0000000000029545.
Hepatitis C is a serious infectious disease caused by the hepatitis C virus (HCV). HCV genotypes (GT) and subtypes are closely related to geographical distribution. Studies on the distribution of HCV genotypes can help to understand the regional epidemiology and genotype distribution and provide benefits in the treatment for hepatitis C. To provide information about the distribution of HCV genotypes as well as improved prevention and treatment of hepatitis C, we aimed to classify the distribution of HCV genotypes among Mongolian and Han patients with hepatitis C in Inner Mongolia over the past 5 years. Peripheral blood samples of patients with HCV were collected for gene sequencing. To analyze the HCV genotype distribution and possible influencing factors, we determined the viral load and ratios of various genotypes. We found that the most prevalent genotype in Inner Mongolia was 1b, followed by GT2a, GT3a, GT3b, and GT6a. The prevalence of HCV among Mongolian patients was significantly higher than the prevalence in their Han counterparts (χ2 = 16.64, P = .000). There was no significant difference in viral load according to sex among HCV genotypes. However, the viral load of GT 1b was significantly higher than that of GT 2a (F = 3.51, P = .008). The viral load of GT 1b among ethnic Mongolians was significantly higher than that among Han patients (t = 2.28, P = .044). The present study's findings can serve as a basis for developing a personalized treatment for hepatitis C among patients in Inner Mongolia.
丙型肝炎是一种由丙型肝炎病毒（HCV）引起的严重传染病。HCV 基因型（GT）和亚型与地理分布密切相关。研究 HCV 基因型的分布有助于了解区域流行病学和基因型分布，并为丙型肝炎的治疗提供益处。为了提供 HCV 基因型分布的信息，并改善丙型肝炎的预防和治疗，我们旨在对过去 5 年内内蒙古地区蒙古族和汉族丙型肝炎患者的 HCV 基因型分布进行分类。采集丙型肝炎患者的外周血样进行基因测序。为了分析 HCV 基因型分布及可能的影响因素，我们测定了病毒载量和各种基因型的比例。我们发现，内蒙古最常见的基因型是 1b，其次是 GT2a、GT3a、GT3b 和 GT6a。蒙古族患者 HCV 的患病率明显高于汉族患者（χ2=16.64，P=0.000）。HCV 各基因型的病毒载量与性别无关。然而，GT1b 的病毒载量明显高于 GT2a（F=3.51，P=0.008）。蒙古族 GT1b 的病毒载量明显高于汉族患者（t=2.28，P=0.044）。本研究结果可为内蒙古患者制定丙型肝炎个体化治疗方案提供依据。
