Gao Yuhua, Yang Jun, Sun Feng, Zhan Siyan, Fang Zhongliao, Liu Xueen, Zhuang Hui
Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Beijing, China.
Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Open Forum Infect Dis. 2019 Feb 6;6(3):ofz040. doi: 10.1093/ofid/ofz040. eCollection 2019 Mar.
Our study aims to estimate the burden of hepatitis C virus (HCV) infection among the general population in Mainland China. We searched 4 databases for studies of the prevalence of anti-HCV antibody among the general population. Studies that met the selection criteria were included in the meta-analysis. Ninety-four studies with 10729 929 individuals were finally included. Overall, the prevalence of anti-HCV antibody among the general population in Mainland China is 0.91% (95% confidence interval, 0.81%-1.03%). The prevalence rates of anti-HCV antibody were geographically different, with a range of 0.32%-6.51%, and the East and South of China had a relatively lower prevalence. The prevalence of anti-HCV antibody increased successively from 0.16% to 3.95% with advancing age. It was noteworthy that the prevalence of anti-HCV antibody decreased continuously from 2.09% to 0.45% during 1991-2010, whereas it increased to 0.58% during 2011-2015.
我们的研究旨在评估中国大陆普通人群中丙型肝炎病毒（HCV）感染的负担。我们检索了4个数据库，以查找普通人群中抗-HCV抗体流行率的研究。符合入选标准的研究被纳入荟萃分析。最终纳入了94项研究，涉及10729929人。总体而言，中国大陆普通人群中抗-HCV抗体的流行率为0.91%（95%置信区间，0.81%-1.03%）。抗-HCV抗体的流行率存在地域差异，范围为0.32%-6.51%，中国东部和南部的流行率相对较低。抗-HCV抗体的流行率随着年龄的增长从0.16%连续上升至3.95%。值得注意的是，抗-HCV抗体的流行率在1991年至2010年期间从2.09%持续下降至0.45%，而在2011年至2015年期间上升至0.58%。
