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微生物的代谢产物。240. 乌达霉素，来自弗氏链霉菌的新型安古霉素类抗生素。II. 乌达霉素B至F的结构研究。

Metabolic products of microorganisms. 240. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. II. Structural studies of urdamycins B to F.

作者信息

Rohr J, Zeeck A

出版信息

J Antibiot (Tokyo). 1987 Apr;40(4):459-67. doi: 10.7164/antibiotics.40.459.

DOI:10.7164/antibiotics.40.459
PMID:3583915
Abstract

The structures of the angucycline antibiotics urdamycin B (5), E (2) and F (9) were established by comparing of their spectra with those of urdamycin A (1). The structures of urdamycins C and D, the largest compounds of this series, are still incomplete (10 and 11). The aglycones urdamycinone C, D and E can be liberated by methanolysis of the corresponding urdamycins. The liberation of urdamycinone B (6) requires an alcohol-free medium, to prevent its rearrangement to the naphthacenequinone 7 or 8. The urdamycins differ from other O-glycoside series in their variety of aglycones.

摘要

通过将安古环素类抗生素乌达霉素B（5）、E（2）和F（9）的光谱与乌达霉素A（1）的光谱进行比较，确定了它们的结构。乌达霉素C和D是该系列中最大的化合物，其结构仍不完整（10和11）。乌达霉素酮C、D和E的苷元可通过相应乌达霉素的甲醇解反应释放出来。释放乌达霉素酮B（6）需要无醇介质，以防止其重排为萘并蒽醌7或8。乌达霉素在苷元种类方面与其他O-糖苷系列不同。

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