CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 110039, China.
Mar Drugs. 2018 May 28;16(6):185. doi: 10.3390/md16060185.
Nine new angucycline glycosides designated urdamycins N1⁻N9 (⁻), together with two known congener urdamycins A () and B (), were obtained from a mangrove-derived subsp. SCSIO GJ056. The structures of new compounds were elucidated on the basis of extensive spectroscopic data analysis. The absolute configurations of ⁻ were assigned by electronic circular dichroism calculation method. Urdamycins N6 () and N9 () represent the first naturally occurring (5, 6)-angucycline glycosides, which are diastereomers of urdamycins N7 () and N8 (), respectively.
从红树林来源的 亚种 SCSIO GJ056 中获得了九个新的安古霉素糖苷，分别命名为 urdamycins N1⁻N9（⁻），以及两个已知的同系物 urdamycins A（）和 B（）。基于广泛的光谱数据分析，确定了新化合物的结构。通过电子圆二色性计算方法确定了 ⁻ 的绝对构型。Urdamycins N6（）和 N9（）分别代表了第一个天然存在的（5,6）-安古霉素糖苷，它们是 urdamycins N7（）和 N8（）的非对映异构体。
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