Hansen T R, Randel R D, Peterson L A
J Anim Sci. 1987 May;64(5):1280-4. doi: 10.2527/jas1987.6451280x.
Two trials evaluated bovine corpus luteum (CL) regression and estrous response following treatment with alfaprostol (AP), a prostaglandin F2 alpha analogue. Expression of at least one estrous cycle (16 to 26 d) and a palpable mid-cycle CL were required prior to random assignment of females to receive 0, .38, .75, 1.50 or 2.25 mg AP/100 kg body weight. Alfaprostol was evaluated in Brahman cows and heifers that were treated on d 11 to 13 (trial 1) and in Simmental X Brahman-Hereford (crossbred) heifers that were treated on d 8 to 10 or d 11 to 13 of the estrous cycle (trial 2). In trial 1, Brahman heifers appeared to require a higher AP dose (greater than .38 mg/100 kg body weight) to elicit luteolysis and expression of estrus than Brahman cows. Alfaprostol treatment (greater than or equal to .75 mg/100 kg body weight) induced (P less than .0001) luteolysis followed by estrus in Brahman cows and heifers. In trial 2, crossbred heifers that received AP on d 8 to 10 appeared to require a higher dose of AP (greater than .38 mg/100 kg body weight) to elicit luteolysis and estrus than heifers that received AP on d 11 to 13 of the estrous cycle. Alfaprostol treatment greater than or equal to .75 mg/100 kg body weight on d 8 to 10 and d 11 to 13 of the estrous cycle induced (P less than .0001) luteolysis followed by estrus in crossbred heifers.(ABSTRACT TRUNCATED AT 250 WORDS)
两项试验评估了用前列醇（AP，一种前列腺素F2α类似物）治疗后牛黄体（CL）的消退情况和发情反应。在将雌性动物随机分配接受0、0.38、0.75、1.50或2.25毫克AP/100千克体重的治疗之前，要求至少有一个发情周期（16至26天）的表现以及可触及的周期中期黄体。在第11至13天对婆罗门牛和小母牛进行了前列醇评估（试验1），在发情周期的第8至10天或第11至13天对西门塔尔×婆罗门-赫里福德（杂交）小母牛进行了前列醇评估（试验2）。在试验1中，婆罗门小母牛似乎比婆罗门母牛需要更高剂量的AP（大于0.38毫克/100千克体重）才能引起黄体溶解和发情表现。前列醇治疗（大于或等于0.75毫克/100千克体重）在婆罗门母牛和小母牛中诱导（P小于0.0001）黄体溶解，随后发情。在试验2中，在发情周期第8至10天接受AP的杂交小母牛似乎比在发情周期第11至13天接受AP的小母牛需要更高剂量的AP（大于0.38毫克/100千克体重）才能引起黄体溶解和发情。在发情周期的第8至10天和第11至13天，大于或等于0.75毫克/100千克体重的前列醇治疗在杂交小母牛中诱导（P小于0.0001）黄体溶解，随后发情。（摘要截短于250字）
