Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China; and.
Retina. 2022 Nov 1;42(11):2110-2119. doi: 10.1097/IAE.0000000000003569.
To describe and analyze clinical characteristics of multifocal choroiditis with linear streaks (LSs).
Eight cases of multifocal choroiditis with LSs were retrospectively studied. Multimodal imaging was performed. Demographic data and spherical equivalent were collected. Axial length was measured.
All cases are young myopic women with a mean age of 17.13 ± 3.64 years (range, 13-23 years), presenting with vision loss and distortion. Nine eyes with LSs were high myopia of -8.97 ± 2.69 D (range, -6.00 to 12.5 D; growing by 1.88 ± 0.61 D annually since wearing glasses), with mean axial length of 26.36 ± 1.71 mm. Vitreous cells were noted in seven eyes. LSs were located in the equator (eight eyes), around the optic disk (three eyes), and at the edge of the posterior pole (one eye). Angio-optical coherence tomography showed choroidal neovascularization in eight eyes, especially 2 to 3 choroidal neovascularizations in three eyes. The location of choroidal neovascularization were in subfovea (three eyes), parafovea (six eyes), and perifovea (two eyes). Swept source optical coherence tomography showed punched-out disruption of retinal pigment epithelium‒Bruch's membrane‒choriocapillaris complex at the LSs' sites. LSs showed fluorescence staining on late FA but hypofluorescence throughout all phases on ICGA.
Multifocal choroiditis with LSs mostly occurs in young women with high myopia, especially occurring in eyes with rapid progression of myopia. LSs are mainly located in the midperiphery near the equator, being prone to concur with choroidal neovascularization. Based on our findings, we propose a new term called "streaky multifocal choroiditis" as a subtype of multifocal choroiditis.
描述并分析多发性脉络膜炎伴线状条纹（LSs）的临床特征。
回顾性研究 8 例多发性脉络膜炎伴 LSs 患者。进行多模态成像。收集人口统计学数据和等效球镜。测量眼轴长度。
所有患者均为年轻近视女性，平均年龄为 17.13 ± 3.64 岁（范围，13-23 岁），表现为视力丧失和变形。9 只眼伴有 LSs 的患者高度近视为-8.97 ± 2.69 D（范围，-6.00 至 12.5 D；自戴眼镜以来每年增长 1.88 ± 0.61 D），平均眼轴长度为 26.36 ± 1.71 mm。7 只眼有玻璃体细胞。LSs 位于赤道（8 只眼）、视盘周围（3 只眼）和后极边缘（1 只眼）。血管光学相干断层扫描显示 8 只眼存在脉络膜新生血管，其中 3 只眼有 2 至 3 处脉络膜新生血管。脉络膜新生血管的位置在黄斑下（3 只眼）、旁黄斑（6 只眼）和中心凹旁（2 只眼）。扫频源光学相干断层扫描显示 LSs 处视网膜色素上皮‒Bruch 膜‒脉络膜毛细血管复合体有打孔样破坏。LSs 在晚期 FA 上显示荧光染色，但在 ICGA 的所有阶段均呈弱荧光。
多发性脉络膜炎伴 LSs 主要发生在年轻高度近视女性中，尤其是在近视快速进展的眼中。LSs 主要位于赤道附近的中周边，易并发脉络膜新生血管。根据我们的发现，我们提出了一个新术语，称为“条纹状多发性脉络膜炎”，作为多发性脉络膜炎的一个亚型。
