Department of psychiatry, First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China; Shanxi Medical University, Taiyuan, Shanxi, China.
Department of Psychiatry, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.
Psychiatry Res. 2022 Sep;315:114697. doi: 10.1016/j.psychres.2022.114697. Epub 2022 Jul 1.
The neurobiology of the Major depressive disorder (MDD) with anxiety is still unclear. The present study aimed to explore the brain correlates of MDD with and without anxiety in men and women during resting-state fMRI.
Two hundred and fifty-four patients with MDD (MDD with anxiety, N = 152) and MDD without anxiety, N = 102) and 228 healthy controls (HCs) participated in this study. We compared the fALFF(fractional amplitude of low-frequency fluctuations) and ReHo(regional homogeneity) of ACC(anterior cingulate cortex) and insula among these three groups. We also compared gender difference between MDD with anxiety and MDD without anxiety.
We found that the fALFF values within the ACC and insula were significantly lower in MDD with anxiety compared to without anxiety and HCs. However, we did not find differences in ReHo values among the three groups. In women, we found significant differences in fALFF values between MDD with and without anxiety. These differences were not observed in men.
It is possible that MDD with anxiety show less spontaneous BOLD-fMRI signal intensity within the ACC and insula compared to MDD without anxiety, especially in women. The fALFF within the ACC and insula can be a potential biomarker for severe MDD phenotype.
伴焦虑的重性抑郁障碍（MDD）的神经生物学机制仍不清楚。本研究旨在利用静息态 fMRI 探讨伴和不伴焦虑的男性和女性 MDD 的脑相关变化。
254 名 MDD 患者（伴焦虑，N=152；不伴焦虑，N=102）和 228 名健康对照（HCs）参与了本研究。我们比较了三组间 ACC（前扣带回）和岛叶的 fALFF（低频振幅分数）和 ReHo（局部一致性）。我们还比较了伴焦虑和不伴焦虑 MDD 之间的性别差异。
我们发现伴焦虑 MDD 的 ACC 和岛叶内的 fALFF 值明显低于不伴焦虑和 HCs。然而，三组间的 ReHo 值无差异。在女性中，我们发现伴和不伴焦虑 MDD 间的 fALFF 值存在显著差异，而在男性中则无差异。
伴焦虑 MDD 的 ACC 和岛叶内的自发 BOLD-fMRI 信号强度可能低于不伴焦虑 MDD，尤其是女性。ACC 和岛叶内的 fALFF 可能是严重 MDD 表型的潜在生物标志物。
