Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.
Department of Sugar Industry and Food Safety Management, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Wólczańska 171/173, 90-924 Lodz, Poland.
Food Chem. 2022 Dec 1;396:133639. doi: 10.1016/j.foodchem.2022.133639. Epub 2022 Jul 8.
The resistance of microorganisms against commonly used antibiotics is becoming an increasingly important problem in the food and pharmaceutical industries. Therefore, the development of novel bactericidal agents, as well as the design of drug delivery systems based on materials composed of biocompatible and biodegradable building blocks, has attracted increasing attention. To address this challenge, microparticles composed of l-lactide homopolymer and l-lactide/1,3-dioxolane (co)polymers loaded with quercetin (Q) were fabricated by using a microfluidic technique. This method enables the preparation of homogeneous particles with sizes ranging from 60 to 80 µm, composed of degradable semicrystalline or amorphous (co)polyesters. The microencapsulation of Q in a (co)polymeric matrix enables prolonged release of the antimicrobial agent. The antibacterial properties of the obtained biocompatible microparticles are confirmed by the agar diffusion plate method for various bacterial strains. Therefore, Q-loaded microparticles can have important applications in food preservation as a novel antimicrobial system.
微生物对常用抗生素的耐药性是食品和制药行业日益面临的重要问题。因此，新型杀菌剂的开发以及基于由生物相容性和可生物降解构建块组成的材料的药物输送系统的设计受到了越来越多的关注。为了解决这一挑战，采用微流控技术制备了由 L-丙交酯均聚物和 L-丙交酯/1,3-二氧戊环（共）聚合物负载槲皮素（Q）组成的微粒。该方法可制备尺寸在 60 至 80 µm 之间的均匀颗粒，由可降解的半结晶或无定形（共）聚酯组成。Q 在（共）聚合物基质中的微囊化可实现抗菌剂的长效释放。琼脂扩散平板法证实了所得生物相容性微粒的抗菌性能对各种细菌菌株有效。因此，负载 Q 的微粒可用作新型抗菌系统在食品保鲜中有重要应用。
