节点预言：淋巴结中的癌细胞重新布线免疫系统，以促进进一步转移。
Node foretold: Cancer cells in lymph node rewire the immune system to enable further metastases.
机构信息
Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Baylor College of Medicine Medical Scientist Training Program, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; The Robert and Janice McNair Foundation MD/PhD Scholars, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Baylor College of Medicine Medical Scientist Training Program, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; McNair Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
出版信息
Cancer Cell. 2022 Aug 8;40(8):812-814. doi: 10.1016/j.ccell.2022.07.001. Epub 2022 Jul 14.
A Cell article reports that lymph node metastases can suppress the immune system, thereby promoting further cancer spread in mouse models; this is corroborated in patients as described in a letter in this issue of Cancer Cell. The lymph node thus actively generates a cancer-permissive environment and is an untapped target to manipulate the immune system.
Cell 杂志上的一篇文章报道称，淋巴结转移可抑制免疫系统，从而促进小鼠模型中的癌症进一步扩散；这在 Cancer Cell 本期发表的一封来信中也得到了患者数据的证实。因此，淋巴结可主动生成有利于癌症的环境，这是一个有待开发的免疫系统调控靶点。
Zotero 插件