Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, China; Department of Neurosurgery, Affiliated Hospital of Putian University, Putian 351100, China.
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, China.
Brain Res. 2022 Oct 1;1792:148014. doi: 10.1016/j.brainres.2022.148014. Epub 2022 Jul 12.
Traumatic brain injury (TBI) is a serious public health problem that endangers human health and is divided into primary and secondary injuries. Previous work has confirmed that changes in cerebral blood flow (CBF) are related to the progression of secondary injury, although clinical studies have shown that CBF monitoring cannot fully and accurately evaluate disease progression. These studies have almost ignored the monitoring of venous blood flow; however, as an outflow channel of the cerebral circulation, it warrants discussion. To explore the regulation of venous blood flow after TBI, the present study established TBI mouse models of different severities, observed changes in cerebral venous blood flow by laser speckle flow imaging, and recorded intracranial pressure (ICP) after brain injury to evaluate the correlation between venous blood flow and ICP. Behavioral and histopathological assessments were performed after the intervention. The results showed that there was a significant negative correlation between ICP and venous blood flow (r = -0.795, P < 0.01), and both recovered to varying degrees in the later stages of observation. The blood flow changes in regional microvessels were similar to those in venous, and the expression of angiogenesis proteins around the impact area was significantly increased. In conclusion, this study based on the TBI mouse model, recorded the changes in venous blood flow and ICP and revealed that venous blood flow can be used as an indicator of the progression of secondary brain injury.
创伤性脑损伤（TBI）是一种严重的公共卫生问题，危害人类健康，分为原发性和继发性损伤。既往工作已经证实，脑血流（CBF）的变化与继发性损伤的进展有关，尽管临床研究表明 CBF 监测不能充分、准确地评估疾病进展。这些研究几乎忽略了对静脉血流的监测；然而，作为脑循环的流出通道，值得讨论。为了探讨 TBI 后静脉血流的调节，本研究建立了不同严重程度的 TBI 小鼠模型，通过激光散斑血流成像观察脑静脉血流的变化，并记录脑损伤后的颅内压（ICP），以评估静脉血流与 ICP 的相关性。干预后进行行为和组织病理学评估。结果表明，ICP 与静脉血流呈显著负相关（r=-0.795，P<0.01），在观察后期均有不同程度的恢复。区域性微血管的血流变化与静脉相似，冲击区周围的血管生成蛋白表达明显增加。总之，本研究基于 TBI 小鼠模型，记录了静脉血流和 ICP 的变化，揭示了静脉血流可以作为继发性脑损伤进展的指标。
