Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China; Research Unit of Critical Infection in Children, 2019RU016, Chinese Academy of Medical Sciences, Beijing, China.
Big Data Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Virol Sin. 2022 Oct;37(5):637-645. doi: 10.1016/j.virs.2022.07.007. Epub 2022 Jul 12.
Epstein-Barr virus (EBV) is very common, with the infection rate in adults over 90% worldwide. Infectious mononucleosis (IM) is caused by primary infection with EBV. Most IM patients are generally considered to have a favorable prognosis, but a few patients will also develop complications. Children with severe symptoms will require hospitalization. However, the disease burden of children hospitalized with IM in China has been rarely described. In this study, we included the Face sheets of discharge medical records from 27 member children's hospitals of Futang Research Center of Pediatric Development from Jan 1st, 2016 to Dec 31st, 2020, and medical information such as gender, age, region, time of admission, length of stay and expenditure were extracted. There were 24,120 IM cases, which accounted for 0.42% (24,120/5,693,262) of all hospitalized cases during this period. The ratio of male to female was 1.48:1. Hospitalization for IM in the 4-6 years age group was the highest among inpatients of all age groups. Case numbers increased year by year between 2016 and 2020, and the monthly hospitalization was generally high from Jul to Sep but reduced from Jan to Feb per year. Bronchitis/pneumonia and hepatic dysfunction were two common complications in hospitalized IM patients. The median length of stay was 8 days, and the median cost of hospitalization was 970.59 US dollars. This study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China.
EB 病毒（EBV）非常常见，全球成年人的感染率超过 90%。传染性单核细胞增多症（IM）是由 EBV 原发感染引起的。大多数 IM 患者一般认为预后良好，但少数患者也会出现并发症。症状严重的儿童需要住院治疗。然而，中国住院 IM 患儿的疾病负担很少有描述。在这项研究中，我们纳入了 Futang 儿童发展研究中心 27 家成员儿童医院 2016 年 1 月 1 日至 2020 年 12 月 31 日出院病案首页信息，提取了性别、年龄、地区、入院时间、住院天数和费用等医疗信息。共纳入 24120 例 IM 病例，占同期住院患儿的 0.42%（24120/5693262）。男女比为 1.48:1。4-6 岁年龄组住院 IM 病例占各年龄组住院病例的比例最高。2016 年至 2020 年，病例数逐年增加，每年 7 月至 9 月的月住院量普遍较高，1 月至 2 月则逐月减少。住院 IM 患儿常见并发症为支气管炎/肺炎和肝功能障碍。中位住院天数为 8 天，中位住院费用为 970.59 美元。本研究将有助于了解中国住院 IM 患儿的流行病学特征和疾病负担。
