Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, BDI Building, Old Road Campus, University of Oxford, Oxford, OX3 7LF, UK.
Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Sci Rep. 2022 Jul 15;12(1):12075. doi: 10.1038/s41598-022-16360-7.
Despite universal vaccination of newborns, the prevalence of chronic hepatitis virus B (HBV) infection and the associated disease burden remain high among adults in China. We investigated risk factors for chronic HBV infection in a community-based study of 512,726 individuals aged 30-79 years recruited from ten diverse areas during 2004-2008. Multivariable logistic regression was used to estimate odds ratios (ORs) of hepatitis B surface antigen (HBsAg) positivity recorded at baseline by sociodemographic and lifestyle factors, and medical history. In a random subset (n = 69,898) we further assessed the association of 18 single nucleotide polymorphisms (SNPs) previously shown to be associated with HBsAg positivity and development of chronic liver disease (CLD) (1600 cases). Several factors showed strong associations with HBsAg positivity, particularly younger age (< 40 vs. ≥ 60 years: OR 1.48, 95% CI 1.32-1.66), male sex (1.40, 1.34-1.46) and urban residency (1.55, 1.47-1.62). Of the 18 SNPs selected, 17 were associated with HBsAg positivity, and 14 with CLD, with SNPs near HLA-DPB1 were most strongly associated with both outcomes. In Chinese adults a range of genetic and non-genetic factors were associated with chronic HBV infection and CLD, which can inform targeted screening to help prevent disease progression.
尽管对新生儿进行了普遍的疫苗接种，但在中国成年人中，慢性乙型肝炎病毒 (HBV) 感染的流行率及其相关疾病负担仍然很高。我们在 2004-2008 年期间，从十个不同地区招募了 512726 名 30-79 岁的个体，进行了一项基于社区的研究，调查了慢性 HBV 感染的危险因素。使用多变量逻辑回归来估计 10 个不同地区招募的 512726 名 30-79 岁的个体的乙型肝炎表面抗原 (HBsAg) 阳性率的比值比（OR），这些个体的乙型肝炎表面抗原（HBsAg）阳性率的比值比（OR）是根据社会人口统计学和生活方式因素以及病史记录的。在一个随机子集中（n=69898），我们进一步评估了 18 个单核苷酸多态性（SNP）与 HBsAg 阳性和慢性肝病（CLD）（1600 例）发展相关的关联。有几个因素与 HBsAg 阳性密切相关，特别是年龄较小（<40 岁与≥60 岁：OR1.48，95%CI1.32-1.66）、男性（1.40，1.34-1.46）和城市居住（1.55，1.47-1.62）。在选择的 18 个 SNP 中，有 17 个与 HBsAg 阳性相关，有 14 个与 CLD 相关，与 HLA-DPB1 附近的 SNP 与两种结果相关性最强。在中国成年人中，一系列遗传和非遗传因素与慢性 HBV 感染和 CLD 相关，这可以为有针对性的筛查提供信息，以帮助预防疾病进展。
