Chun -Yu, Cheng, Chang Gung Memorial Hospital, 199, Tun-Hwa North Road, Taipei 105, Taiwan, Telephone: +886-2-27135211-3397, Email:
J Prev Alzheimers Dis. 2022;9(3):441-448. doi: 10.14283/jpad.2022.23.
Varicose vein may be related to increased risk of comorbidities and decreased cognitive function in the elderly, but little is known about the association between varicose vein and Alzheimer's disease.
To evaluate whether there is an association between varicose veins and Alzheimer's disease.
The study subjects of this cohort study were selected based on Chang Gung Research Database from January 1, 2003, to December 31, 2012. Follow-up ended December 31, 2017.
A population-based study Participants: Patients aged 45 years and older with varicose veins were enrolled, and the participants of control group were selected by matching with gender, age, and index date at a 4:1 ratio.
The hazard ratios associated with varicose veins were estimated using Cox regression analysis with competitive risk model. Incidence rates of Alzheimer's disease, was assessed in people with and without varicose veins.
A total of 9,601 patients with varicose veins and 38,404 matched controls were enrolled in the study. The varicose veins group had higher incidence rates than the control group for Alzheimer's disease (12.60 vs 6.24 per 10,000 person-years; Hazard ratio, 1.647 [95% confidence interval, 1.326- 2.045, p<0.001]). Patients with complicated varicose veins had increased incidence of Alzheimer's disease than uncomplicated cases (adjusted HR, 1.474; 95% CI, 1.034-2.101, P=0.032).
The present study demonstrated a positive association between the varicose veins and Alzheimer's disease. Physicians should be alerted to cognitive function in patients with varicose veins, especially those with presence of inflammation and ulcerations.
静脉曲张可能与老年人的合并症风险增加和认知功能下降有关，但关于静脉曲张与阿尔茨海默病之间的关系知之甚少。
评估静脉曲张与阿尔茨海默病之间是否存在关联。
本队列研究的研究对象选自 2003 年 1 月 1 日至 2012 年 12 月 31 日的长庚研究数据库。随访于 2017 年 12 月 31 日结束。
基于人群的研究。参与者：纳入年龄在 45 岁及以上的静脉曲张患者，并以性别、年龄和指数日期 4:1 的比例匹配选择对照组参与者。
使用竞争风险模型的 Cox 回归分析估计与静脉曲张相关的风险比。评估静脉曲张患者和无静脉曲张患者的阿尔茨海默病的发病率。
共纳入 9601 例静脉曲张患者和 38404 例匹配对照。静脉曲张组的阿尔茨海默病发生率高于对照组（12.60 比 6.24/10000 人年；风险比，1.647[95%置信区间，1.326-2.045，p<0.001]）。患有复杂静脉曲张的患者比单纯静脉曲张患者发生阿尔茨海默病的风险更高（调整后的 HR，1.474；95%CI，1.034-2.101，P=0.032）。
本研究表明静脉曲张与阿尔茨海默病之间存在正相关关系。医生应该警惕静脉曲张患者的认知功能，尤其是那些存在炎症和溃疡的患者。
