Dolan P, Adams M A, Hutton W C
J Bone Joint Surg Br. 1987 May;69(3):422-8. doi: 10.1302/0301-620X.69B3.3584198.
Cadaveric lumbar discs were injected with chymopapain and subjected to a series of mechanical tests over a period of up to 19 hours. Discs from the same spine injected with saline were used as controls. The results showed that chymopapain had no measurable effect on the mechanical properties of the disc apart from the increased height and stiffening caused by fluid injection. Another series of tests on isolated pieces of disc material showed that chymopapain could reduce the size of prolapsed nuclear material by 24% in one hour and by 80% in 48 hours. It is concluded that, in the short-term, chymopapain has a negligible effect on the mechanics of a disc but it can reduce the size of any prolapsed nuclear material with which it comes in contact.
将木瓜凝乳蛋白酶注入尸体腰椎间盘，并在长达19小时的时间内进行一系列力学测试。将注入生理盐水的同一脊柱的椎间盘用作对照。结果表明，除了液体注入导致的椎间盘高度增加和变硬外，木瓜凝乳蛋白酶对椎间盘的力学性能没有可测量的影响。另一系列对分离的椎间盘材料片的测试表明，木瓜凝乳蛋白酶可在1小时内使脱出的核物质尺寸减小24%，在48小时内减小80%。得出的结论是，短期内，木瓜凝乳蛋白酶对椎间盘力学的影响可忽略不计，但它可以减小与之接触的任何脱出核物质的尺寸。
