贲门癌胃切除术后阳性近端切缘的预防和治疗。
Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer.
机构信息
Department of Surgery, University Hospital of Donostia, Donostia-San Sebastián, Spain.
Department of Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK.
出版信息
Updates Surg. 2023 Feb;75(2):335-341. doi: 10.1007/s13304-022-01315-4. Epub 2022 Jul 16.
Abstract
A tumour-positive proximal margin (PPM) after extended gastrectomy for oesophagogastric junction (OGJ) adenocarcinoma is observed in approximately 2-20% of patients. Although a PPM is an unfavourable prognostic factor, the clinical relevance remains unclear as it may reflect poor tumour biology. This narrative review analyses the most relevant literature on PPM after gastrectomy for OGJ cancers. Awareness of the risk factors and possible measures that can be taken to reduce the risk of PPM are important. In patients with a PPM, surgical and non-surgical treatments are available but the effectiveness remains unclear.
摘要
在胃食管结合部腺癌行扩大胃切除术的患者中，约有 2-20%观察到肿瘤阳性近端切缘（PPM）。虽然 PPM 是一个不利的预后因素，但由于其可能反映了肿瘤生物学较差，其临床相关性尚不清楚。本叙述性综述分析了关于胃切除术治疗 OGJ 癌症后 PPM 的最相关文献。了解 PPM 的风险因素以及可能采取的降低 PPM 风险的措施非常重要。对于 PPM 患者，可采用手术和非手术治疗，但治疗效果尚不清楚。
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