Dacey R G, Bassett J E
J Cereb Blood Flow Metab. 1987 Jun;7(3):327-31. doi: 10.1038/jcbfm.1987.70.
Histamine from various sources is found in significant amounts around cerebral vessels and may play a significant role in controlling CBF. The effect of histamine on the intracerebral microcirculation has not been examined. We have used an in vitro technique for the isolation and cannulation of intracerebral arterioles from the rat to study the effect of histamine on the spontaneous tone developed by these vessels. Extraluminally administered histamine caused dose-dependent vasodilation of isolated intracerebral arterioles with a maximal dilation of 139 +/- 2.4% of control diameter. The dilation was blocked by the H2 receptor antagonist cimetidine, but was only incompletely attenuated by the H1 receptor blocker chlorpheniramine. Histamine effects a dilation of the spontaneous tone of intracerebral resistance vessels, which is mediated by H2 receptors.
在脑血管周围发现了大量来自各种来源的组胺，其可能在控制脑血流量方面发挥重要作用。组胺对脑内微循环的影响尚未得到研究。我们使用一种体外技术从大鼠脑中分离并插管脑内小动脉，以研究组胺对这些血管自发张力的影响。经血管外给予组胺可引起离体脑内小动脉剂量依赖性血管舒张，最大舒张幅度为对照直径的139±2.4%。这种舒张作用被H2受体拮抗剂西咪替丁阻断，但仅被H1受体阻滞剂氯苯那敏部分减弱。组胺可引起脑内阻力血管自发张力的舒张，这是由H2受体介导的。
