从腈亚胺和胍衍生物合成功能化的 3-氨基-1,2,4-三唑。
A synthesis of functionalized 3-amino-1,2,4-triazoles from nitrile imines and guanidine derivatives.
机构信息
Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran.
出版信息
Mol Divers. 2024 Feb;28(1):11-18. doi: 10.1007/s11030-022-10471-z. Epub 2022 Jul 17.
PMID:35842885
Abstract
A regioselective synthesis of trisubstituted 1,2,4-triazoles through reaction of nitrile imines with guanidine derivatives is described. These 1,3-dipolar cycloaddition reactions proceeded smoothly in moderate to good yields and excellent regioselectivity under ambient conditions. This method provides fast access to a range of functionalized 3-amino-1,2,4-triazoles.
摘要
本文描述了一种通过腈亚胺与胍衍生物反应来合成三取代 1,2,4-三唑的区域选择性方法。这些 1,3-偶极环加成反应在温和条件下以中等到良好的收率和优异的区域选择性顺利进行。该方法为一系列功能化的 3-氨基-1,2,4-三唑提供了快速的合成途径。
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