Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Radiology, University Hospital of North-Norway, Tromsø, Norway; Department of Clinical Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.
Eur J Radiol. 2022 Sep;154:110425. doi: 10.1016/j.ejrad.2022.110425. Epub 2022 Jun 27.
To describe the findings of focal high signal on T2 weighted (T2W) images of the bone marrow in the axial skeleton as assessed by whole-body MRI in healthy and asymptomatic children and adolescents.
We assessed the bone marrow of the mandible, shoulder girdle, thorax, spine, and pelvis on water-only Dixon T2W sequences as part of a whole-body MRI protocol in 196 healthy and asymptomatic children aged 5-19 years. Intensity (0-2 scale) and extension (1-4 scale) of focal high signal areas in the bone marrow were scored and divided into minor or major findings, based on intensity and extension to identify the potentially conspicuous lesions in a clinical setting.
We registered 415 areas of increased signal in the axial skeleton whereof 75 (38.3%) were major findings. Fifty-eight (29.6%) individuals had at least one major finding, mainly located in the pelvis (54, 72%). We found no differences according to gender. The number of minor findings increased with age (p = 0.020), but there were no significant differences in the number of major findings. The most conspicuous findings were in the pelvis, spine and sternum.
Non-specific bone marrow T2W hyperintensities in the axial skeleton are frequently detected on whole-body MRI in healthy, asymptomatic children. Awareness of this is important as some findings may resemble clinically silent lesions in children with suspected multifocal skeletal disease.
描述全身 MRI 评估的健康无症状儿童和青少年轴骨骨髓 T2 加权（T2W）图像上局灶性高信号的发现。
我们在 196 名 5-19 岁健康无症状儿童的全身 MRI 方案中评估了下颌骨、肩部、胸部、脊柱和骨盆的骨髓，在水激发 Dixon T2W 序列上评估骨髓。对骨髓中局灶性高信号区域的强度（0-2 级）和延伸（1-4 级）进行评分，并根据强度和延伸将其分为次要或主要发现，以在临床环境中识别潜在明显的病变。
我们在轴骨中记录了 415 个信号增强区域，其中 75 个（38.3%）为主要发现。58 名（29.6%）个体至少有一个主要发现，主要位于骨盆（54 个，72%）。我们没有发现性别差异。次要发现的数量随年龄增加（p=0.020），但主要发现的数量没有显著差异。最明显的发现是在骨盆、脊柱和胸骨。
在健康无症状儿童的全身 MRI 上经常检测到轴骨骨髓 T2W 高信号，无特异性。了解这一点很重要，因为一些发现可能类似于怀疑多灶性骨骼疾病的儿童的临床无症状病变。
