Angenete Oskar W, Haustreis Janne, Aune Lisbeth K, Lundestad Anette, Cetrelli Lena, Augdal Thomas Angell, Nordal Ellen Berit, Grønning Kjersti, Rygg Marite
Department of Radiology and Nuclear Medicine, St Olav Hospital HF, Trondheim University Hospital, Trondheim, Norway.
Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
PLoS One. 2025 Jun 3;20(6):e0325069. doi: 10.1371/journal.pone.0325069. eCollection 2025.
Modern paediatric healthcare is increasingly dependent on diagnostic methods such as imaging and blood samples. These methods require knowledge of physiology and anatomy to separate signs of early disease development from physiological variants. To acquire this knowledge, researchers depend on studies on children from the general populations, but little is known about how children and their guardians experience participation in studies. This study aims to map the experiences of children participating in research.
From a cohort of children and guardians from the general population, participating as controls in a large study on juvenile idiopathic arthritis (NorJIA), a subset was invited to share their experiences. The participants were examined using blood sampling, MRI, x-ray, bone-density scan, anthropometric measurements, and questionnaires. A questionnaire of 26 questions regarding their experiences from the study was sent out 2-4 weeks after the data collection.
The questionnaire was filled out by 50 children and 50 guardians. A large majority of the children responded that they were positive to help researchers, that blood sample procedures and imaging procedures went well, that they would participate in the study again, and would recommend their friends to take part in similar studies. Guardians generally responded positively, but there were diverging responses between children and guardians.
Children from the general population reported mainly positive experiences from participation in research, including imaging and blood sampling. The experiences of the children and their guardians are sometimes diverging, underpinning the importance of addressing the child's opinions.
现代儿科医疗越来越依赖于成像和血液样本等诊断方法。这些方法需要生理学和解剖学知识，以便将早期疾病发展的迹象与生理变异区分开来。为了获得这些知识，研究人员依赖于对普通人群中儿童的研究，但对于儿童及其监护人如何体验参与研究却知之甚少。本研究旨在梳理参与研究的儿童的经历。
从普通人群中的一组儿童及其监护人中，选取作为青少年特发性关节炎大型研究（NorJIA）对照组的一部分，邀请他们分享自己的经历。对参与者进行了血液采样、MRI、x光、骨密度扫描、人体测量和问卷调查。在数据收集后2至4周，发放了一份关于他们在研究中的经历的包含26个问题的问卷。
50名儿童和50名监护人填写了问卷。绝大多数儿童表示他们愿意帮助研究人员，血液采样程序和成像程序进展顺利，他们愿意再次参与该研究，并会推荐他们的朋友参加类似的研究。监护人总体上反应积极，但儿童和监护人之间存在不同的回答。
普通人群中的儿童报告参与研究（包括成像和血液采样）的经历主要是积极的。儿童及其监护人的经历有时存在差异，这突出了听取儿童意见的重要性。
