Division of Neuroradiology, Department of Radiology, University of Michigan, 1500 East Medical Center Drive, UH B2, Ann Arbor, MI 48109, USA.
Division of Neuroradiology, Department of Radiology, University of Michigan, 1500 East Medical Center Drive, UH B2, Ann Arbor, MI 48109, USA.
Neuroimaging Clin N Am. 2022 Aug;32(3):683-698. doi: 10.1016/j.nic.2022.04.010.
Understanding normal brain aging physiology is essential to improving healthy human longevity, differentiation, and early detection of diseases, such as neurodegenerative diseases, which are an enormous social and economic burden. Functional decline, such as reduced physical activity and cognitive abilities, is typically associated with brain aging. The authors summarize the aging brain mechanism and effects of aging on the brain observed by brain structural MR imaging and advanced neuroimaging techniques, such as diffusion tensor imaging and functional MR imaging.
了解正常的大脑衰老生理学对于改善健康人类的长寿、分化和疾病的早期检测至关重要，如神经退行性疾病，这是一个巨大的社会和经济负担。功能下降，如体力活动和认知能力的降低，通常与大脑衰老有关。作者总结了大脑结构磁共振成像和扩散张量成像、功能磁共振成像等先进神经影像学技术观察到的大脑衰老机制和衰老对大脑的影响。
