不同n-回溯任务期间与年龄相关的大脑变化：一项功能近红外光谱研究
Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study.
作者信息
Zhu Shizhe, Wang Qinglei, Kan Chaojie, Geng Ayan, Sui Youxin, Zhuang Ren, Zhu Yi, Wang Tong, Zhu Lan, Guo Chuan
机构信息
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Rehabilitation Medicine, Changzhou Dean Hospital, Changzhou, China.
出版信息
Front Aging Neurosci. 2024 Oct 16;16:1437587. doi: 10.3389/fnagi.2024.1437587. eCollection 2024.
BACKGROUND
The n-back task is a widely used paradigm to assess working memory and is commonly applied in research on age-related cognitive decline. However, studies utilizing functional near-infrared spectroscopy (fNIRS) to explore this area are limited.
OBJECTIVE
This study aims to investigate age-related differences in brain activation during the n-back task using fNIRS.
METHODS
fNIRS data were collected from 18 elderly and 19 young participants while performing different n-back tasks. Brain activation patterns and peripheral performance were compared between the two groups.
RESULTS
Significant differences in brain activation patterns were observed between elderly and young participants. Under the 3-back condition, the older group exhibited reduced activation in brain regions adjacent to prefrontal cognitive areas compared to the younger group. Additionally, the older group's performance plateaued at the 2-back level, along with a decline in prefrontal activation.
CONCLUSION
These findings may suggest potential markers for cognitive decline, providing a new target for future screening.
背景
n-回溯任务是一种广泛用于评估工作记忆的范式，常用于与年龄相关的认知衰退研究。然而，利用功能近红外光谱技术（fNIRS）探索该领域的研究有限。
目的
本研究旨在使用fNIRS研究n-回溯任务期间大脑激活的年龄差异。
方法
在18名老年人和19名年轻人执行不同的n-回溯任务时收集fNIRS数据。比较两组之间的大脑激活模式和外周表现。
结果
老年人和年轻人的大脑激活模式存在显著差异。在3-回溯条件下，与年轻组相比，老年组在前额叶认知区域相邻的脑区激活减少。此外，老年组的表现在2-回溯水平达到平稳，同时前额叶激活下降。
结论
这些发现可能提示认知衰退的潜在标志物，为未来的筛查提供了新靶点。
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