Laboratory of Visceral System Physiology, Institute of Experimental Medicine, St. Petersburg, Russia.
Bull Exp Biol Med. 2022 Jul;173(3):302-305. doi: 10.1007/s10517-022-05538-8. Epub 2022 Jul 18.
Changes in pulmonary microhemodynamics in response to pulmonary embolism under conditions of activation of K channels with nicorandil, Kv channels with dapagliflozin, and BK channels with Evans blue were studied on isolated rabbit lungs. Under conditions of activation of K and BK channels, the constrictor reactions of the pulmonary arterial vessels during embolization of the pulmonary artery were less pronounced than in the control. Activation of BK channels reduced constrictor reactions of the pulmonary venous vessels, while activation of K and Kv channels eliminates them. The shifts of the capillary filtration coefficient are determined to a greater extent by the pre-/postcapillary resistance ratio, than by changes of the endothelial permeability. Pretreatment with dapagliflozin led to a decrease in the capillary filtration coefficient. It was established, that nimesulide exhibits properties of a BK-channel activator.
在离体兔肺上研究了尼可地尔激活 K 通道、达格列净激活 Kv 通道和 Evans 蓝激活 BK 通道条件下，肺栓塞时肺微血管血液动力学的变化。在 K 和 BK 通道激活的情况下，与对照组相比，肺动脉栓塞时肺动脉血管的收缩反应不那么明显。BK 通道的激活降低了肺静脉血管的收缩反应，而 K 和 Kv 通道的激活则消除了这种反应。毛细血管滤过系数的变化在更大程度上取决于前/后毛细血管阻力比，而不是内皮通透性的变化。达格列净预处理可降低毛细血管滤过系数。结果表明，尼美舒利具有 BK 通道激活剂的特性。
