Tetar Shyama U, Bruynzeel Anna M E, Verweij Lisa, Bohoudi Omar, Slotman Berend J, Rosario Tezontl, Palacios Miguel A, Lagerwaard Frank J
Department of Radiation Oncology, Amsterdam University Medical Centers, Location VUmc, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Phys Imaging Radiat Oncol. 2022 Jul 3;23:92-96. doi: 10.1016/j.phro.2022.06.013. eCollection 2022 Jul.
Magnetic resonance-guided radiotherapy with daily plan adaptation for intermediate- and high-risk prostate cancer is time and labor intensive. Fifty adapted plans with 3 mm planning target volume (PTV)-margin were compared with non-adapted plans using 3 or 5 mm margins. Adequate (V95% ≥ 95%) prostate coverage was achieved in 49 fractions with 5 mm PTV without plan adaptation, however, coverage of the seminal vesicles (SV) was insufficient in 15 of 50 fractions. There was no insufficient coverage for prostate and SV using plan adaptation with 3 mm. Hence, daily adaptation is recommended to obtain adequate SV-coverage when using 3 mm PTV.
针对中高危前列腺癌的每日计划调整的磁共振引导放疗耗时且费力。将50个采用3毫米计划靶区（PTV）边界的调整计划与采用3或5毫米边界的未调整计划进行比较。在未进行计划调整的情况下，使用5毫米PTV时，49次分割可实现足够的（V95%≥95%）前列腺覆盖，但在50次分割中有15次精囊（SV）覆盖不足。采用3毫米的计划调整时，前列腺和精囊没有覆盖不足的情况。因此，建议在使用3毫米PTV时进行每日调整以获得足够的精囊覆盖。
