Lu Dasheng, Zou Xinyue, Zhang Hongxiang
Department of Cardiology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, China.
Vascular Diseases Research Center of Wannan Medical College, Wuhu, China.
Front Cardiovasc Med. 2022 Jul 1;9:948755. doi: 10.3389/fcvm.2022.948755. eCollection 2022.
Atrial fibrillation (AF) is characterized by high morbidity and disability rate. The incidence of AF has rapidly increased due to increased aging population, causing a serious burden on society and patients. Therefore, it is necessary to determine the prevention and treatment of AF. Several studies have assessed the occurrence, development mechanism, and intervention measures of AF. The human gut has several non-pathogenic microorganisms forming the gut flora. The human gut microbiota plays a crucial role in the construction and operation of the metabolic system and immune system. Emerging clinical studies and basic experiments have confirmed that intestinal flora and its metabolites have a role in some metabolic disorders and chronic inflammatory diseases. Moreover, the gut microbiota has a role in cardiovascular diseases, such as hypertension and heart failure. However, the relationship between AF and gut microbiota is unclear. This review summarizes the relevant literature on the relationship between AF and intestinal flora with its metabolites, including Trimethylamine N-Oxide, short-chain fatty acids, lipopolysaccharide and bile acids. Therefore, this review may enhance further development of related research.
心房颤动（AF）的特点是发病率和致残率高。由于人口老龄化加剧，AF的发病率迅速上升，给社会和患者造成了沉重负担。因此，确定AF的预防和治疗方法很有必要。多项研究评估了AF的发生、发展机制及干预措施。人体肠道中有多种非致病微生物形成肠道菌群。人体肠道微生物群在代谢系统和免疫系统的构建与运行中起着关键作用。新兴的临床研究和基础实验已证实，肠道菌群及其代谢产物在某些代谢紊乱和慢性炎症性疾病中发挥作用。此外，肠道微生物群在心血管疾病如高血压和心力衰竭中也有作用。然而，AF与肠道微生物群之间的关系尚不清楚。本综述总结了关于AF与肠道菌群及其代谢产物（包括氧化三甲胺、短链脂肪酸、脂多糖和胆汁酸）之间关系的相关文献。因此，本综述可能会促进相关研究的进一步发展。
