Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Jiangsu, Suzhou, China.
Front Cell Infect Microbiol. 2022 Nov 10;12:1059349. doi: 10.3389/fcimb.2022.1059349. eCollection 2022.
In recent years, due to the development and widespread utilization of metagenomic sequencing and metabolomics, the relationship between gut microbiota and human cardiovascular diseases (CVDs) has received extensive attention. A growing number of studies have shown a strong relationship between gut microbiota and CVDs, such as coronary atherosclerosis, hypertension (HTN) and heart failure (HF). It has also been revealed that intestinal flora-related metabolites, such as trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFA) and bile acids (BAs), are also related to the development, prevention, treatment and prognosis of CVDs. In this review, we presented and summarized the recent findings on the relationship between gut microbiota and CVDs, and concluded several currently known gut microbiota-related metabolites and the occurrence and development of CVDs.
近年来，由于宏基因组测序和代谢组学的发展和广泛应用，肠道微生物群与人类心血管疾病（CVDs）之间的关系受到了广泛关注。越来越多的研究表明，肠道微生物群与 CVDs 之间存在密切关系，如冠状动脉粥样硬化、高血压（HTN）和心力衰竭（HF）。此外，还发现肠道菌群相关代谢物，如三甲胺-N-氧化物（TMAO）、短链脂肪酸（SCFA）和胆汁酸（BAs），也与 CVDs 的发生、预防、治疗和预后有关。在这篇综述中，我们介绍和总结了肠道微生物群与 CVDs 之间关系的最新研究结果，并总结了几种目前已知的与肠道微生物群相关的代谢物与 CVDs 的发生和发展的关系。
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