Bergfelt Lennmyr Emma, Engvall Marie, Barbany Gisela, Fogelstrand Linda, Rhodin Hanna, Hallböök Helene
Department of Medical Sciences Uppsala University Uppsala Sweden.
Department of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden.
EJHaem. 2021 Sep 22;2(4):813-817. doi: 10.1002/jha2.300. eCollection 2021 Nov.
Cytogenetic aberrations are recognized as important prognostic factors in adult acute lymphoblastic leukemia (ALL), but studies seldom include elderly patients. From the population-based Swedish ALL Registry, we identified 728 patients aged 18-95 years, who were diagnosed with ALL 1997-2015 and had cytogenetic information. Registry data were complemented with original cytogenetic reports. was the most recurrent aberration, with a frequency of 26%, with additional cytogenetic alterations in 64%. rearrangement was the second most frequent aberration found in 7%. Low hypodiploidy-near triploidy and complex karyotype had negative impact, while t(1;19); showed positive impact on overall survival. However, after correction for age only complex karyotype remained significant.
细胞遗传学异常被认为是成人急性淋巴细胞白血病（ALL）的重要预后因素，但相关研究很少纳入老年患者。我们从基于人群的瑞典ALL登记处中，识别出728例年龄在18 - 95岁之间、于1997 - 2015年被诊断为ALL且有细胞遗传学信息的患者。登记处数据由原始细胞遗传学报告补充。 是最常见的异常，频率为26%，64%的患者有额外的细胞遗传学改变。 重排是第二常见的异常，发生率为7%。低亚二倍体 - 近三倍体和复杂核型有负面影响，而t(1;19) 对总生存期有正面影响。然而，在校正年龄后，只有复杂核型仍具有显著性。
