Duarte Dejair da Silva, Teixeira Eliel Barbosa, de Oliveira Marcelo Braga, Carneiro Thiago Xavier, Leão Lucyana Barbosa Cardoso, Mello Júnior Fernando Augusto Rodrigues, Carneiro Debora Monteiro, Nunes Patricia Ferreira, Cohen-Paes Amanda, Alcantara Diego Di Felipe Ávila, Khayat André Salim, Burbano Rommel Mario Rodriguez
Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém 66073-000, Brazil.
Hospital Ophir Loyola, Belém 66063-240, Brazil.
Biomedicines. 2024 Nov 29;12(12):2739. doi: 10.3390/biomedicines12122739.
Acute lymphoblastic leukemia (ALL) is an aggressive neoplasm derived from B and/or T cell lineage (B-ALL; T-ALL). For the first time, this study describes, cytogenetically, the karyotypic alterations in adults with ALL in the northern region of Brazil and their relationship with hematological and biochemical characteristics. Through banding analyses, immunophenotyping, as well as hematological and biochemical examination data obtained directly from patients' records, we found that chromosome 21 aneuploidy was the most frequent. The cytogenetic structural alterations observed with the highest incidence among the patients were: t(9;22), t(4;11), t(1;19), del(6q), and del(9p). In patients presenting with chromosome alterations, we verified that patients with t(4;11) have elevated red blood cell levels and patients with del(9p) presented with distinct and high values of hematological parameters compared to other patients. Regarding biochemical alterations, we observed that patients with translocations (4;11) and del(6q) presented with elevated urea levels compared to other patients, highlighting its relationship to kidney changes and patient prognosis. Thus, our study highlights that variations in hematological and biochemical data are associated with specific cytogenetic changes and other factors, which may impact the prognosis of adult patients with ALL.
急性淋巴细胞白血病（ALL）是一种源自B和/或T细胞谱系的侵袭性肿瘤（B-ALL；T-ALL）。本研究首次从细胞遗传学角度描述了巴西北部成年ALL患者的核型改变及其与血液学和生化特征的关系。通过显带分析、免疫表型分析以及直接从患者记录中获取的血液学和生化检查数据，我们发现21号染色体非整倍体最为常见。在患者中观察到的细胞遗传学结构改变发生率最高的有：t(9;22)、t(4;11)、t(1;19)、del(6q)和del(9p)。在出现染色体改变的患者中，我们证实t(4;11)患者的红细胞水平升高，而del(9p)患者的血液学参数值与其他患者相比明显更高。关于生化改变，我们观察到与其他患者相比，发生(4;11)易位和del(6q)的患者尿素水平升高，突出了其与肾脏变化和患者预后的关系。因此，我们的研究强调血液学和生化数据的变化与特定的细胞遗传学改变及其他因素相关，这可能会影响成年ALL患者的预后。
