Thain Serene, McMicking Jess, de Naurois Julien, Nelson-Piercy Catherine
Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore, Singapore.
Department of Obstetrics and Gynaecology, Guy's and St Thomas' Hospital, London, UK.
Obstet Med. 2022 Jun;15(2):141-145. doi: 10.1177/1753495X20987047. Epub 2021 Mar 9.
Gastrointestinal cancer occurs in approximately 1 in 13,000 pregnancies, making up 4% of malignancies detected in pregnancy. It is a complex and challenging condition to diagnose and manage and is often only detected in its more advanced stages. This is partly due to symptoms of gastrointestinal cancer being incorrectly attributed to physiological symptoms of pregnancy, as well as concerns about the safety of diagnostic investigations in pregnancy, both of which may delay diagnosis and lead to disease progression. Challenges in management also arise from under-treatment in pregnancy due to concerns about the impact of surgery or chemotherapy on the pregnancy. We present here three cases of gastrointestinal cancer diagnosed in pregnancy in our centre and discuss the challenges and pitfalls one may encounter in the diagnosis and management of gastrointestinal malignancies in pregnancy.
胃肠道癌症在大约每13000例妊娠中出现1例,占孕期检测到的恶性肿瘤的4%。它是一种诊断和管理复杂且具有挑战性的疾病,通常仅在更晚期才被发现。部分原因是胃肠道癌症的症状被错误地归因于妊娠的生理症状,以及对孕期诊断检查安全性的担忧,这两者都可能延迟诊断并导致疾病进展。由于担心手术或化疗对妊娠的影响,孕期治疗不足也会带来管理方面的挑战。我们在此展示我们中心诊断出的三例孕期胃肠道癌症病例,并讨论在孕期胃肠道恶性肿瘤的诊断和管理中可能遇到的挑战和陷阱。