Hoge S K, Biederman J
J Clin Psychopharmacol. 1987 Apr;7(2):87-9.
Results of liver function tests in 42 children and adolescents treated with desipramine for up to 24 months were unchanged. Although tricyclic-related hepatotoxicity cannot be ruled out with a small sample, it does not appear to be a dose- or time-related phenomenon in this age group.
42名接受去甲丙咪嗪治疗长达24个月的儿童和青少年的肝功能测试结果未发生变化。虽然不能排除小样本量情况下三环类药物相关肝毒性的可能性,但在这个年龄组中,它似乎不是一种与剂量或时间相关的现象。