Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Contrast Media Mol Imaging. 2022 Jun 29;2022:7012377. doi: 10.1155/2022/7012377. eCollection 2022.
The clinical risk profile of paroxysmal atrial fibrillation (pAF) patients is inconclusive. We aimed to identify clinical and laboratory biomarkers in patients with pAF and the differences in biomarkers among genders. A cross-sectional study was conducted with a total of 181 participants in a single center in Beijing Anzhen Hospital. The participants were grouped according to the presence of pAF and sex differences, and clinical and laboratory results were collected and compared. The 181 participants had a mean age of 52.9 ± 15.1 years (pAF group, 60.4 ± 9.9 years, SR group, 48.3 ± 15.9 years, < 0.05). Patients with pAF had significantly higher rates of age, left atrial (LA) diameter, haemoglobin (Hb) levels, tissue inhibitor of metalloproteinase-1 (TIMP-1), soluble tumour suppressor-2 (sST2), B-type natriuretic peptide (BNP) and indirect bilirubin (Ibil), mean haemoglobin concentration (MCHC), and hypertension (HTN) and smoking ( < 0.05). Multivariable logistic regression analysis revealed that age (OR = 1.075, 95% CI: 1.035-1.118, < 0.0001), smoking (OR = 4.538, 95% CI: 1.559-13.205, = 0.006), and MCHC (OR = 1.062, 95% CI: 1.019-1.106, = 0.004) were independent predictive factors for pAF. Multivariable logistic regression analysis found that age (OR = 1.107, 95% CI: 1.016-1.206, = 0.02) and Ibil level (OR = 2.303, 95% CI: 1.158-4.582, = 0.017) were independent predictive factors of the occurrence of pAF in females; BNP (OR = 1.015, 95% CI: 1.002-1.029, = 0.029) was an independent predictive variable of pAF in males. Age, smoking, and MCHC were independent predictive factors of pAF. BNP was an independent predictive biomarker of pAF in males, while in females, age and Ibil were independent predictive factors.
阵发性心房颤动（pAF）患者的临床风险特征尚无定论。我们旨在确定 pAF 患者的临床和实验室生物标志物以及不同性别之间生物标志物的差异。这项横断面研究共纳入了北京安贞医院的 181 名参与者。根据是否存在 pAF 和性别差异对参与者进行分组，并收集和比较临床和实验室结果。181 名参与者的平均年龄为 52.9±15.1 岁（pAF 组为 60.4±9.9 岁，SR 组为 48.3±15.9 岁， < 0.05）。pAF 患者的年龄、左心房（LA）直径、血红蛋白（Hb）水平、组织金属蛋白酶抑制剂-1（TIMP-1）、可溶性肿瘤抑制物-2（sST2）、B 型利钠肽（BNP）和间接胆红素（Ibil）、平均血红蛋白浓度（MCHC）、高血压（HTN）和吸烟率明显更高（ < 0.05）。多变量逻辑回归分析显示，年龄（OR = 1.075，95%CI：1.035-1.118， < 0.0001）、吸烟（OR = 4.538，95%CI：1.559-13.205， = 0.006）和 MCHC（OR = 1.062，95%CI：1.019-1.106， = 0.004）是 pAF 的独立预测因素。多变量逻辑回归分析发现，年龄（OR = 1.107，95%CI：1.016-1.206， = 0.02）和 Ibil 水平（OR = 2.303，95%CI：1.158-4.582， = 0.017）是女性 pAF 发生的独立预测因素；BNP（OR = 1.015，95%CI：1.002-1.029， = 0.029）是男性 pAF 的独立预测变量。年龄、吸烟和 MCHC 是 pAF 的独立预测因素。BNP 是男性 pAF 的独立预测生物标志物，而女性中，年龄和 Ibil 是独立预测因素。
