Yoshihara Kyoko, Nannya Yasuhito, Matsuda Ikuo, Samori Mami, Utsunomiya Nobuto, Okada Masaya, Hirota Seiichi, Ogawa Seishi, Yoshihara Satoshi
Department of Hematology Hyogo College of Medicine Hospital Nishinomiya Japan.
Department of Pathology and Tumor Biology Kyoto University Kyoto Japan.
EJHaem. 2021 Dec 3;3(1):211-214. doi: 10.1002/jha2.354. eCollection 2022 Feb.
A 64-year-old man with angioimmunoblastic T-cell lymphoma (AITL) subsequently developed diffuse large B-cell lymphoma (DLBCL) and myelodysplastic syndrome (MDS). Genomic profiling of AITL, DLBCL, and MDS samples revealed that the tumor cells from all samples shared common mutations in and . In addition, the mutation was observed in AITL, and mutation was observed in DLBCL and MDS. These findings illustrate the clonal relationship between AITL and DLBCL in addition to AITL and MDS, with the latter being increasingly reported. The present findings strongly support the theory of multistep and multilineage tumorigenesis from a common founder clone.
一名64岁患有血管免疫母细胞性T细胞淋巴瘤（AITL）的男性患者随后发展为弥漫性大B细胞淋巴瘤（DLBCL）和骨髓增生异常综合征（MDS）。对AITL、DLBCL和MDS样本进行的基因组分析显示，所有样本中的肿瘤细胞在 和 中存在共同突变。此外，在AITL中观察到 突变，在DLBCL和MDS中观察到 突变。这些发现说明了AITL与DLBCL之间以及AITL与MDS之间的克隆关系，后者的报道日益增多。目前的研究结果有力地支持了从一个共同的始祖克隆发生多步骤和多谱系肿瘤发生的理论。
