多哥年轻女性乳腺癌的组织分子特征
Histo-Molecular Profile of Breast Cancer in Young Women in Togo.
作者信息
Djiwa Toukilnan, Koui Baumaney, Simgban Panakinao, Mézéwè Sama Bagassam, Bombonne Mayi, Doukouré Brahima, Darré Tchin
机构信息
Department of Pathological Anatomy, Teaching Hospital of Lomé, Lome, Togo.
Department of Pathological Anatomy, Teaching Hospital of Abidjan, Abidjan, Ivory Coast.
出版信息
Clin Pathol. 2022 Jul 12;15:2632010X221112452. doi: 10.1177/2632010X221112452. eCollection 2022 Jan-Dec.
INTRODUCTION
The frequency of breast cancer in young women, corresponding to women under 40 years of age; varies from 5% to 7% in developed countries. The objective of this study was to contribute to the improvement of the management of breast cancer in young women in Togo, by establishing the molecular classification of these cancers.
METHODOLOGY
This was a retrospective descriptive and analytical study from January 2010 to December 2020.
RESULTS
About 35 cases of breast cancer were identified in women under 40 years of age. The average age was 35.4 ± 3.5 years. The right breast was affected in 18 cases (51.43%). Histologically, 30 cases (85.72%) were invasive carcinoma of no special type (NST), 2 cases (5.71%) were invasive lobular carcinoma and micro-papillary carcinoma respectively, and 1 case (2.86%) was tubular carcinoma. There were 6 cases (17.1%) of grade I, 25 cases (71.4%) of grade II, and 4 cases (11.4%) of grade III. Molecularly, there were 20 cases (57.1%) of triple-negative subtype, 6 cases (17.1%) of Luminal B subtype, 05 cases (14.3%) of HER2-enriched subtype and 4 cases (11.4%) of Luminal A subtype.
CONCLUSION
Breast cancers of young Togolese women express very weakly hormone receptors, with a predominance of a triple negative subtype.
引言
年轻女性（40岁以下）乳腺癌的发病率在发达国家为5%至7%。本研究的目的是通过建立这些癌症的分子分类，为改善多哥年轻女性乳腺癌的管理做出贡献。
方法
这是一项2010年1月至2020年12月的回顾性描述性和分析性研究。
结果
在40岁以下女性中确定了约35例乳腺癌病例。平均年龄为35.4±3.5岁。右侧乳房受累18例（51.43%）。组织学上，30例（85.72%）为非特殊类型浸润性癌（NST），2例（5.71%）分别为浸润性小叶癌和微乳头癌，1例（2.86%）为管状癌。I级6例（17.1%），II级25例（71.4%），III级4例（11.4%）。分子水平上，三阴性亚型20例（57.1%），Luminal B亚型6例（17.1%），HER2富集亚型5例（14.3%），Luminal A亚型4例（11.4%）。
结论
多哥年轻女性乳腺癌激素受体表达非常弱，以三阴性亚型为主。
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