Gu Renjun, Xia Yawen, Li Pengfei, Zou Defang, Lu Keqin, Ren Lang, Zhang Hongru, Sun Zhiguang
Nanjing University of Chinese Medicine, Nanjing, China.
Jiangsu Provincial Second Chinese Medicine Hospital, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Front Cell Dev Biol. 2022 Jun 30;10:860344. doi: 10.3389/fcell.2022.860344. eCollection 2022.
Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. Currently, surgery is the treatment of choice for GC. However, the associated expenses and post-surgical pain impose a huge burden on these patients. Furthermore, disease recurrence is also very common in GC patients, thus necessitating the discovery and development of other potential treatment options. A growing body of knowledge about ferroptosis in different cancer types provides a new perspective in cancer therapeutics. Ferroptosis is an iron-dependent form of cell death. It is characterized by intracellular lipid peroxide accumulation and redox imbalance. In this review, we summarized the current findings of ferroptosis regulation in GC. We also tackled on the action of different potential drugs and genes in inducing ferroptosis for treating GC and solving drug resistance. Furthermore, we also explored the relationship between ferroptosis and the tumor microenvironment in GC. Finally, we discussed areas for future studies on the role of ferroptosis in GC to accelerate the clinical utility of ferroptosis induction as a treatment strategy for GC.
胃癌（GC）是全球第五大常见癌症，也是癌症相关死亡的第三大主要原因。目前，手术是胃癌的首选治疗方法。然而，相关费用和术后疼痛给这些患者带来了巨大负担。此外，疾病复发在胃癌患者中也非常常见，因此需要发现和开发其他潜在的治疗选择。关于不同癌症类型中铁死亡的知识不断增加，为癌症治疗提供了新的视角。铁死亡是一种铁依赖性的细胞死亡形式。其特征是细胞内脂质过氧化物积累和氧化还原失衡。在这篇综述中，我们总结了目前胃癌中铁死亡调节的研究结果。我们还探讨了不同潜在药物和基因在诱导铁死亡以治疗胃癌和解决耐药性方面的作用。此外，我们还探讨了胃癌中铁死亡与肿瘤微环境之间的关系。最后，我们讨论了未来关于铁死亡在胃癌中的作用的研究领域，以加速诱导铁死亡作为胃癌治疗策略的临床应用。
