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印度北部一家三级医疗中心关于硬化性苔藓临床谱的研究。

A study on clinical spectrum of lichen sclerosus in a tertiary care Centre in North India.

作者信息

Brar Sukhmani Kaur, Bano Rubeena, Puri Neerja, Singh Amarbir

机构信息

Fortis Clinic, Mohali, Punjab, India.

Demographic Characteristics, Demographic Distribution, G G S Medical College, Faridkot, Punjab, India.

出版信息

Indian J Sex Transm Dis AIDS. 2022 Jan-Jun;43(1):43-46. doi: 10.4103/ijstd.ijstd_126_20. Epub 2022 Jun 7.

DOI:10.4103/ijstd.ijstd_126_20
PMID:35846549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9282700/
Abstract

INTRODUCTION

Lichen sclerosus (LS) is a chronic dermatosis frequently located over labial, perineal, and perianal areas. The etiology is multifactorial and includes genetic, autoimmune, hormonal, and infectious aspects.

MATERIALS AND METHODS

A series of twenty genital LS patients was carried out to evaluate the signs, symptoms, complications, and affliction of quality of life.

RESULTS

Eighteen out of twenty patients were female between 30 and 73 years and showed smooth, glistening, and whitish plaques. The mean duration was 8.4 years. Itching and burning was the most common symptom (75%) corresponding to excoriation and fissuring of genitalia (75%). Malignancy was seen in two cases (10%). The mean Vulvar Quality of Life Index was 9.2, higher in younger patients.

DISCUSSION

LS is a disorder of older age group with female preponderance. It is a source of significant morbidity, and long-standing cases predispose to vulvar malignancy.

CONCLUSION

To conclude, early diagnosis with proper counselling of the patient and his/her partner regarding various aspects of disease are essential for a wholesome approach.

摘要

引言

硬化性苔藓(LS)是一种慢性皮肤病,常发生于阴唇、会阴和肛周区域。其病因是多因素的,包括遗传、自身免疫、激素和感染等方面。

材料与方法

对一系列20例生殖器LS患者进行评估,以了解其体征、症状、并发症及生活质量受影响情况。

结果

20例患者中有18例为女性,年龄在30至73岁之间,表现为光滑、发亮的白色斑块。平均病程为8.4年。瘙痒和灼痛是最常见的症状(75%),对应于生殖器的擦伤和皲裂(75%)。2例(10%)出现恶变。外阴生活质量指数平均为9.2,年轻患者更高。

讨论

LS是一种老年人群的疾病,女性居多。它是严重发病的根源,长期病例易发生外阴恶性肿瘤。

结论

总之,早期诊断并就疾病的各个方面对患者及其伴侣进行适当的咨询,对于全面的治疗方法至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd3/9282700/b4f432fff361/IJSTD-43-43-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd3/9282700/ed9935dc6dd5/IJSTD-43-43-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd3/9282700/839acbfe21c1/IJSTD-43-43-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd3/9282700/a624baa97c47/IJSTD-43-43-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd3/9282700/b4f432fff361/IJSTD-43-43-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd3/9282700/ed9935dc6dd5/IJSTD-43-43-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd3/9282700/839acbfe21c1/IJSTD-43-43-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd3/9282700/a624baa97c47/IJSTD-43-43-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd3/9282700/b4f432fff361/IJSTD-43-43-g008.jpg

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Australas J Dermatol. 2020 May;61(2):110-118. doi: 10.1111/ajd.13197. Epub 2019 Nov 14.
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Lichen Sclerosus Accompanied by Urethral Squamous Cell Carcinoma: A Retrospective Study From a Urethral Referral Center.
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British Association of Dermatologists guidelines for the management of lichen sclerosus, 2018.英国皮肤科医师协会2018年扁平苔藓硬化症管理指南
Br J Dermatol. 2018 Apr;178(4):839-853. doi: 10.1111/bjd.16241.
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