Errante Emily L, Diaz Anthony, Smartz Taylor, Khan Aisha, Silvera Risset, Brooks Adriana E, Lee Yee-Shuan, Burks S Shelby, Levi Allan D
The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United States.
Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United States.
Front Cell Neurosci. 2022 Jul 1;16:929494. doi: 10.3389/fncel.2022.929494. eCollection 2022.
Peripheral nerve injury (PNI) is found in a relatively large portion of trauma patients. If the injury is severe, such as with the presence of a long segmental gap, PNI can present a challenge for treatment. The current clinical standard of nerve harvest for the repair of long segmental gap PNI can lead to many potential complications. While other methods have been utilized, recent evidence indicates the relevance of cell therapies, particularly through the use of Schwann cells, for the treatment of PNI. Schwann cells (SCs) are integral in the regeneration and restoration of function following PNI. SCs are able to dedifferentiate and proliferate, remove myelin and axonal debris, and are supportive in axonal regeneration. Our laboratory has demonstrated that SCs are effective in the treatment of severe PNI when axon guidance channels are utilized. However, in order for this treatment to be effective, optimal techniques for cellular placement must be used. Thus, here we provide relevant background information, preclinical, and clinical evidence for our method in the treatment of severe PNI through the use of SCs and axon guidance channels.
外周神经损伤（PNI）在相当一部分创伤患者中都有发现。如果损伤严重，比如存在长节段间隙，PNI的治疗就会面临挑战。目前用于修复长节段间隙PNI的临床神经采集标准可能会导致许多潜在并发症。虽然已经采用了其他方法，但最近的证据表明细胞疗法，特别是通过使用雪旺细胞，在PNI治疗中的相关性。雪旺细胞（SCs）在PNI后的再生和功能恢复中不可或缺。SCs能够去分化和增殖，清除髓鞘和轴突碎片，并支持轴突再生。我们实验室已经证明，当使用轴突导向通道时，SCs在治疗严重PNI方面是有效的。然而，为了使这种治疗有效，必须使用最佳的细胞放置技术。因此，在这里我们提供了相关的背景信息、临床前和临床证据，以说明我们通过使用SCs和轴突导向通道治疗严重PNI的方法。
