Center for Translational Immunology, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia.
Front Cell Infect Microbiol. 2022 Jun 30;12:909888. doi: 10.3389/fcimb.2022.909888. eCollection 2022.
and are human-specific pathogens in the Neisseriaceae family that can cause devastating diseases. Although both species inhabit mucosal surfaces, they cause dramatically different diseases. Despite this, they have evolved similar mechanisms to survive and thrive in a metal-restricted host. The human host restricts, or overloads, the bacterial metal nutrient supply within host cell niches to limit pathogenesis and disease progression. Thus, the pathogenic require appropriate metal homeostasis mechanisms to acclimate to such a hostile and ever-changing host environment. This review discusses the mechanisms by which the host allocates and alters zinc, manganese, and copper levels and the ability of the pathogenic to sense and respond to such alterations. This review will also discuss integrated metal homeostasis in and the significance of investigating metal interplay.
和 是奈瑟氏菌科中的人类特异性病原体，可导致毁灭性疾病。尽管这两种物种都栖息在粘膜表面，但它们引起的疾病却大不相同。尽管如此，它们已经进化出相似的机制，以在金属受限的宿主中生存和繁殖。人类宿主限制（或过载）宿主细胞龛位中的细菌金属营养供应，以限制发病机制和疾病进展。因此，致病性 需要适当的金属稳态机制来适应这种恶劣且不断变化的宿主环境。本综述讨论了宿主分配和改变锌、锰和铜水平的机制，以及致病性 感知和响应这种改变的能力。本综述还将讨论 和 中的综合金属稳态以及研究金属相互作用的意义。
