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Hum Brain Mapp. 2021 Nov;42(16):5495-5518. doi: 10.1002/hbm.25631. Epub 2021 Aug 20.
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健康个体与精神分裂症患者感觉及感觉运动门控中多巴胺能和胆碱能机制的比较分析

Comparative Analysis of Dopaminergic and Cholinergic Mechanisms of Sensory and Sensorimotor Gating in Healthy Individuals and in Patients With Schizophrenia.

作者信息

Proshin Andrey T

机构信息

P. K. Anokhin Institute of Normal Physiology, Moscow, Russia.

出版信息

Front Behav Neurosci. 2022 Jun 30;16:887312. doi: 10.3389/fnbeh.2022.887312. eCollection 2022.

DOI:10.3389/fnbeh.2022.887312
PMID:35846783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9282644/
Abstract

Sensory and sensorimotor gating provide the early processing of information under conditions of rapid presentation of multiple stimuli. Gating deficiency is observed in various psychopathologies, in particular, in schizophrenia. However, there is also a significant proportion of people in the general population with low filtration rates who do not show any noticeable cognitive decline. The review article presents a comparative analysis of existing data on the peculiarities of cholinergic and dopaminergic mechanisms associated with lowering gating in healthy individuals and in patients with schizophrenia. The differences in gating mechanisms in cohorts of healthy individuals and those with schizophrenia are discussed.

摘要

感觉和感觉运动门控在多种刺激快速呈现的条件下对信息进行早期处理。在各种精神病理学中，尤其是精神分裂症中观察到门控缺陷。然而，普通人群中也有很大一部分人的过滤率较低，但没有表现出任何明显的认知衰退。这篇综述文章对健康个体和精神分裂症患者中与门控降低相关的胆碱能和多巴胺能机制的特点的现有数据进行了比较分析。讨论了健康个体队列和精神分裂症患者队列中门控机制的差异。