Haß Katharina, Bak Nikolaj, Szycik Gregor R, Glenthøj Birte Y, Oranje Bob
Clinic for Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hanover, Germany; Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Mental Health Services, Capital Region of Denmark, University of Copenhagen, Denmark.
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Mental Health Services, Capital Region of Denmark, University of Copenhagen, Denmark.
Biol Psychol. 2017 Sep;128:112-116. doi: 10.1016/j.biopsycho.2017.07.016. Epub 2017 Jul 25.
To investigate whether the typically reported deficient sensorimotor gating in patients with schizophrenia using unimodal paradigms can also be detected by a cross-modal paradigm which made use of an electrocutaneous-acoustic coupling of stimuli.
Twenty-one male schizophrenia patients took part in a prepulse inhibition (PPI) paradigm with an electrocutaneous prepulse and an acoustic startle-eliciting pulse. Their results were compared with those from nineteen healthy males.
As expected, the patients showed significantly lower PPI than controls. No associations were found between measures of illness severity and PPI.
To the best of our knowledge, this is the first study showing reduced PPI in patients with schizophrenia by using an electrocutaneous-acoustic prepulse-pulse combination. Hence, this study gives further evidence of a modality-independent sensorimotor gating deficit in schizophrenia. Furthermore, as PPI was also lower than usual in controls using unimodal paradigms, results are interpreted in favour of longer processing times of the electrocutaneous prepulse, which probably led to a shorter perceived stimulus onset asynchrony (SOA) in the brain.
研究使用单峰范式时典型报道的精神分裂症患者感觉运动门控缺陷是否也能通过利用刺激的皮肤电 - 听觉耦合的跨峰范式检测到。
21名男性精神分裂症患者参与了一项采用皮肤电预脉冲和听觉惊吓诱发脉冲的预脉冲抑制（PPI）范式。将他们的结果与19名健康男性的结果进行比较。
正如预期的那样，患者的PPI显著低于对照组。未发现疾病严重程度指标与PPI之间存在关联。
据我们所知，这是第一项通过使用皮肤电 - 听觉预脉冲 - 脉冲组合显示精神分裂症患者PPI降低的研究。因此，本研究进一步证明了精神分裂症中存在与模式无关的感觉运动门控缺陷。此外，由于在使用单峰范式的对照组中PPI也低于通常水平，结果表明皮肤电预脉冲的处理时间更长，这可能导致大脑中感知到的刺激起始异步（SOA）更短。
