Medvedev Alexei, Buneeva Olga
Laboratory of Pharmacoproteomics, Institute of Biomedical Chemistry, Moscow, Russia.
Front Behav Neurosci. 2022 Jun 30;16:922274. doi: 10.3389/fnbeh.2022.922274. eCollection 2022.
Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of the indole nucleus. Although these stages require concerted action of bacterial and host enzymes, there are two pathways of isatin formation: the host and bacterial pathways. Isatin acts as a neuroprotector in different experimental models of neurodegeneration. Its effects are realized up- and downregulation of isatin-responsive genes and interaction with numerous isatin-binding proteins identified in the brain. The effect of isatin on protein-protein interactions in the brain may be important for realization of weak inhibition of multiple receptor targets.
异吲哚酮（吲哚 -2,3-二酮）是一种内源性调节剂，具有多种行为、生物学和药理活性。异吲哚酮的合成包括几个关键阶段：色氨酸侧链的裂解以及吲哚核的后续氧化。尽管这些阶段需要细菌和宿主酶的协同作用，但异吲哚酮的形成有两条途径：宿主途径和细菌途径。在不同的神经退行性疾病实验模型中，异吲哚酮起着神经保护作用。其作用是通过上调和下调异吲哚酮反应性基因以及与在大脑中鉴定出的多种异吲哚酮结合蛋白相互作用来实现的。异吲哚酮对大脑中蛋白质 - 蛋白质相互作用的影响可能对实现对多个受体靶点的微弱抑制很重要。
