Hu Chenyan, Heng Pengfei, Zeng Yuanyuan, Zhang Qing, Zhao Meilian, Yang Zhongzhu, He Yang
State Key Laboratory of Southwestern Chinese Medicine Resources, College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, China.
Department of Laboratory Medicine, People's Hospital of Xinjin District, Chengdu, Sichuan 611430, China.
ACS Omega. 2022 Jun 23;7(27):23708-23716. doi: 10.1021/acsomega.2c02328. eCollection 2022 Jul 12.
Common pathogenic bacteria contaminate the environment through various modes of transmission. It is thus crucial to develop simple preparation methods of residue-free environmental disinfectants. β-Lactam antibiotics are frequently prescribed in clinical practice to treat bacterial infections. In this study, we used electrochemical exfoliation to synthesize graphene oxide (GO) with abundant ketene functional groups. A residue-free GO-β-lactam (GOβL) was subsequently obtained by mixing ketene and azomethine-H via a [2 + 2] cycloaddition reaction in the aqueous phase. GOβL has shown broad-spectrum bacterial inhibition against four bacteria (, , , and ), and it degrades rapidly within 24 h. This study provides a fast and easy method for the synthesis of GOβL, which can be employed as a promising environmental bacteriostatic disinfectant in real-life applications.
常见病原菌通过多种传播方式污染环境。因此，开发简单的无残留环境消毒剂制备方法至关重要。β-内酰胺类抗生素在临床实践中常用于治疗细菌感染。在本研究中，我们采用电化学剥离法合成了具有丰富乙烯酮官能团的氧化石墨烯（GO）。随后，通过乙烯酮与甲亚胺-H在水相中进行[2 + 2]环加成反应，得到了无残留的GO-β-内酰胺（GOβL）。GOβL对四种细菌（、、和）表现出广谱抑菌作用，且在24小时内迅速降解。本研究提供了一种快速简便的GOβL合成方法，其可在实际应用中作为一种有前景的环境抑菌消毒剂。
